Not just Holistic, but how to use E: All of the Above!

I made this blog because I did tons of research on success stories and research worldwide and used it on my dog with nasal cancer named Lucy. So, now my hobby is molecular biology. The treatment uses combination of health store supplements, some prescription meds, diet changes, and specific Ayurvedic and Chinese medicinal herbs. I just wanted her to have a better quality of life. I thought this combination of E: All the Above (except no radiation or chemo and surgery for this cancer was not an option) would help that for sure, but it actually put her bleeding nasal cancer in remission!
My approach to cancer is about treating the whole animals biologic system. But I do hate the word 'Holistic'. Sounds like hoo hoo. This is science based, research based data and results of using active herbal compounds that happen to be readily available and common. Some call it Nutriceuticals. Others may call it Orthomolecular cancer therapy. Or Cancer Immunotherapy.
I FEEL DIVERSITY IN TREATMENT IS KEY:
-Slow cancer cell reproduction
-Make cancer cells become easier targets for the immune system
-Kill the cancer cells
-Rid the cancer cells
-Remove the toxins it produces
- Stimulate and Modulate the immune system
-Control secondary symptoms like bleeding, infection, inflammation, mucous, appetite, or pain for a better feeling animal
-Working with your vet for exams and prescriptions that are sometimes needed when conditions are acute.
Just by using a multi-modal treatment approach that is as diverse in attack as possible. Both conventional and natural.
The body conditions that allowed it to develop in the first place must be corrected. If caught early enough, like with Lucy, this ongoing maintenance correctional treatment is all that was required at this point to achieve, so far, more than 10 TIMES the life expectancy given (more than 60 months) after diagnosis WITH remission. I did not use radiation or chemotherapy or surgery.
I hope this cancer research can help your dog as well.

My Lucy

My Lucy
In Loving Memory my Lucy December 2016
CURRENT STATUS - It was for more than 5 YEARS after Lucy was diagnosed by biopsy in March 2011 with nasal cancer that she lived. And she was in remission for 4 of 5 years using no radiation or chemo! Now multiply that by 7 to be 35 years extended!! She was 12.5 years old - equivalent to almost 90 human years old. She ended her watch December 1, 2016. I miss her so much.

March 17, 2017

Cannabinoids cannabidiol from hemp for dog cancers


What is CBD? What is CBD Oil?
Cannabidiol (CBD) is a naturally occurring constituent of industrial hemp/cannabis. Its formula is C21H30O2 and it has a molecular mass of 314.4636. It is the most abundant non-psychoactive cannabinoid found in cannabis, and is being scientifically investigated for various reasons.
Cannabidiol—CBD—is a hemp/cannabis derived compound that has significant medical benefits, but does not make people feel “stoned” and can actually counteract the psychoactivity of THC.
CBD oil is a cannabis oil (whether derived from marijuana or industrial hemp, as the word cannabis is the latin genus name for both) that has significant amounts of cannabidiol (CBD) contained within it. CBD products and extracts are also derived from industrial hemp, so they could be considered CBD-rich hemp oil, hemp derived CBD oil, CBD-rich cannabis oil, or plainly “hemp extracts” since they typically contain much more than just CBD. Again, cannabis doesn't mean marijuana, but is the genus name, and general umbrella term which all forms of marijuana and hemp fall under. 
What’s the difference between Hemp and Marijuana?
To better understand the difference, we need to get botanical. Hemp and marijuana are different varieties of the same plant species Canabis Sativa L. It’s like how dogs and wolves are different breeds of Canis Lupis. They are related but differ in scientific make-up and how they are cultivated or bred. For example, hemp is made to grow upward like bamboo (10-15’ high) specifically for its stalks and seeds which are used for textiles, food, paper, body care products, plastics and building materials. That’s why it’s most often referred to as “industrial hemp”.

Marijuana, on the other hand, is grown out like a bush to cultivate the leaves and cannabis flowers used for medicinal and recreational purposes.

David P. West, PhD of the North American Industrial Hemp Council and renowned commercial corn breeder explains that a biochemical method further classifies Cannabis plants by their unique molecular compounds called cannabinoids - the most common being CBD and THC. Marijuana is low in CBD and contains 5-10% THC which is the psychoactive ingredient that gives a “high”. Industrial hemp conversely is high in CBD and has a low .3-1.5% level of THC and considered non-narcotic. 

Scientifically when it comes to naming, industrial Hemp and Marijuana are the same plant, with a genus and species using the name of Cannabis Sativa. BUT they have a drastically different genetic profile though. Industrial Hemp is always a strain of Cannabis sativa, while marijuana can be Cannabis sativa, Cannabis indica, or Cannabis ruderalis. The major difference is how industrial hemp has been bred compared to a marijuana form of Cannabis sativa. Typically speaking, industrial hemp is very fibrous, with long strong stalks, and barely has any flowering buds, while a marijuana strain of Cannabis sativa will be smaller, bushier, and full of flowering buds. However, newer industrial hemp varieties in the USA are being bred to have more flowers and higher yields of cannabinoids and terpenes, but no THC.
99% of the time marijuana has a high amount of psychoactive THC and only a very low amount of CBD. Hemp, on the other hand, naturally has a very high amount of CBD in most instances, and only a trace amount of pyschoactive THC. Fortunately, the cannabinoid profile of hemp is ideal for people looking for benefits from cannabis without the ‘high.’ Hemp is used for making herbal supplements, food, fiber, rope, paper, bricks, oil, natural plastic, and so much more, whereas marijuana is usually used just recreationally, spiritually, and medicinally. The term cannabis oil can refer to either a marijuana or hemp derived oil, since marijuana and hemp are two different forms of cannabis.
In the USA the legal definition of “industrial hemp,” per Section 7606 of the Agricultural Appropriations Act of 2014, is “INDUSTRIAL HEMP — The term ‘‘industrial hemp’’ means the plant Cannabis sativa L. and any part of such plant, whether growing or not, with a delta-9 tetrahydrocannabinol concentration of not more than 0.3 percent on a dry weight basis.”
Are hemp derived cannabinoids such as CBD as good as CBD from marijuana?
The short answer is yes. CBD is CBD, whether from marijuana or hemp. Most marijuana has a very low non-psychoactive cannabinoid profile (like CBD, CBC, CBG), so most of the time hemp would be much more preferable for anything besides THC. Marijuana is usually very high in THC (gives people the high) but usually very low in other non-psychoactive cannabinoids.
Is a standard hemp seed oil the same as a high-CBD hemp extract?
Absolutely not. Standard hemp seed oil, which can be found very cheaply at a grocery store, is a much different product than hemp extracts (not from seed). Standard hemp oil is produced by cold pressing the seeds, whereas hemp extract is a supercritical CO2 extraction of the hemp plant itself, not the seeds. Hemp seed oil is considered to be a great nutritive food, but it doesn't have the naturally occurring terpenes, cannabinoids and other components that our extracts do have.
Will you get ‘high’?
No. Hemp Extract products are all made from industrial hemp, which only has trace amounts of THC, so there is no psychoactive effect. 
What is the endocannabinoid system (ECS)?
“The endocannabinoid system (ECS) is a group of endogenous cannabinoid receptors located in the mammalian brain and throughout the central and peripheral nervous systems, consisting of neuromodulatory lipids and their receptors.” Wikipedia
There are two main types of receptors in the ECS, CB1 and CB2. CB1 receptors are primarily located in the central nervous system and brains of mammals, and CB2 are generally found in the peripheral nervous system. There are two main cannabinoids mammals produce- 2AG and Anandamide (named after the Sanskrit term “ananda” which translates to “peace”).
For hundreds of millions of years every vertebrate on Earth (which obviously would include dogs and cats!) has been equipped with this ECS, a crucial system in the body, and it has been known about in the scientific and medical communities since the 1980’s. However, this body system still not taught about in most medical schools due to politics.
Scientific research has shown CBD may be therapeutic for many conditions. In compiling a list of conditions that CBD may help, we examined hundreds of peer-reviewed articles in scientific journals. Relevant reports have been culled primarily from PubMed, online service of the U.S. National Library of Medicine. To these highly technical reports, we have added articles from O'Shaughnessy's and a few stories from general interest publications. 
Most of the PubMed material consists of abstracts on preclinical research involving single cannabinoid molecules, test tubes, petri dishes, animal experiments, and in some cases human cell-line studies. Although all mammals have cell receptors that respond pharmacologically to cannabinoid compounds, data from animal experiments and other preclinical research is not always applicable to humans. GW Pharmaceuticals has conducted successful trials of Sativex, a whole plant CBD-rich cannabis extract, mainly for people suffering from neuropathic pain; summaries of this research are also included. There have been additional studies with synthetic CBD and whole plant cannabis in Brazil and Israel. Unfortunately, political constraints have blocked clinical-oriented CBD research in the United States.
Most of the reports that follow pertain to cannabidiol. Occasionally articles examine the therapeutic potential of other plant cannabinoids—THC, CBDA (cannabidiol in its raw acid form), THCV, CBG, and CBDV, for example. I've also included a few studies that illuminate various aspects of the endocannabinoid system without focusing on CBD.

Cancer


General

Bladder

Brain

Breast

Colon

Endocrine

Kaposi Sarcoma

Leukemia

Lung

Pain

Prostate

Skin




Inflammation





Nausea




Neuropathic Pain


Epilepsy & Seizure Disorders



Owner Survey:


  • 92.6% of ALL respondents favored CBD cannibinoids to SOME, MOST or ANY medications*
  • 73.0% report CBD INHIBITED CELL GROWTH IN TUMORS / CANCER CELLS*
  • 95.0% report CBD provides PAIN RELIEF*
  • 82.3% report CBD helps REDUCE VOMITING OR NAUSEA*
*Survey conducted by Colorado State University, published in the Journal of the AHVMA, 2016. Results are from 457 dog owners, with an opinion, confirming that products like Canna-Pet® products have helped a moderate amount or a lot with individual issues.


I haven’t seen any official scientific studies done on dogs proving the claimed benefits CBD (if you know of one, please contact me) but there is a lot of anecdotal evidence at the below links that makes it appear to be a pretty promising health supplement. However, there have been various pre-clinical, general cannabis research done on both humans and lab animals that prove there is some medical benefit in those cases. It’s not a large leap of faith to assume that dogs can experience similar benefits as humans and lab animals.

Read all the testimonials on pets, it's pretty wild.

https://canna-pet.com/testimonials/

https://www.bluebird-botanicals.com/product/classic-hemp-10ml/   I just ordered this for myself to try it on me and my wife

https://www.treatibles.com/blogs/updates?page=1

https://www.petreleaf.com/cbd/customer-reviews

 https://cbdpettreats.us/shop/dog-treats-cbd-5mg/



I didn't get the chance to use this myself in time for Lucy. I regret not trying it on her.



Lucy never did radiation or chemo, she only did the Tippner Protocol. The Tippner Cancer Protocol combines immunotherapy and molecular cancer therapy using off the shelf readily available inexpensive natural substances. Here is her list. She lived more than 5 years after diagnosis by biopsy

I buy most of the stuff from Swanson Vitamins. They are cheaper, in capsules for dosage changes, and carry almost everything I give to Lucy except for the Chinese Herbs Stasis Breaker prescription, Yunnan Bai Yao for bleeding, and the Low Dose Naltrexone prescription.


Posted by Unknown at 6:19 PM
Labels: , ,

March 6, 2017

Dog Breed Median Life Expectancy in Years



Well, it's been a little more than 90 days since she died and I have not posted.
Any of you who need help I will still help you, so please email me anytime. It's only fair. The universe gave me more than 5 years instead of 4 months.

I am posting this so we might have an idea when maybe our fight might be drawing down simply due to an aging immune system. I really felt bad about Lucy for much of the last 90 days but this I guess tells me I might have not been able to really keep her going for alot longer.




Breed                              Median Life Expectancy in Years
Affenpinscher.......................................... 11 .42
Afghan hound.......................................... 11 .92
Airedale terrier........................................ 10 .75
Akita........................................................ 9 .92
Alaskan Malamute.................................. 10 .71
American cocker spaniel......................... 10 .33
Anatolian/Karabash................................. 10 .75
Australian cattle dog............................... 11 .67     LUCY WAS THIS WITH SOME LAB MIX - SHE MADE IT TO 12.5 YEARS WITH CANCER 
Australian shepherd................................ 9
Australian silky terrier............................ 14 .25
Australian terrier..................................... 12 .08
Basenji..................................................... 13.54
Basset Fauve de Bretagne....................... 10 .42
Basset Griffon Vendeen.......................... 12 .04
Basset hound........................................... 11 .29
Beagle...................................................... 12 .67
Bearded collie......................................... 13 .5
Bedlington terrier.................................... 13 .38
Belgian shepherd..................................... 12 .5
Bernese mountain dog............................. 8
Bichon frise............................................. 12 .92
Bloodhound............................................. 6 .79
Border collie............................................ 12 .25
Border terrier........................................... 14
Borzoi...................................................... 9 .08
Boston terrier.......................................... 10 .92
Bouvier Des Flandres.............................. 11 .33
Boxer....................................................... 10 .25
Briard....................................................... 11 .17
Brittany.................................................... 12 .88
Bull terrier............................................... 10
Bulldog.................................................... 6 .29
Bull mastiff.............................................. 7 .46
Cairn terrier............................................. 14
Canaan dog.............................................. 14 .63
Cavalier King Charles spaniel................ 11 .38
Cesky terrier............................................ 8 .42
Chesapeake Bay retriever....................... 10 .75
Chihuahua................................................ 12 .42
Chinese crested....................................... 10 .08
Chow Chow............................................. 9 .38
Clumber spaniel...................................... 10 .33
Cocker spaniel......................................... 11 .17
Collie....................................................... 12 .67
Curly coated retriever............................. 10 .75
Dachshund............................................... 12 .67
Dalmatian................................................ 12 .5
Dandie Dinmont terrier........................... 12 .17
Deer hound............................................... 8 .67
Doberman.............................................. 10 .5
Dogue de Bordeaux................................. 3 .83
English setter........................................... 11 .58
English springer spaniel.......................... 12
English toy terrier................................... 12
Field spaniel............................................ 11 .63
Finnish Lapphund.................................... 7 .33
Finnish spitz............................................ 11 .13
Flat-coated retriever................................ 9 .83
Fox terrier................................................ 13 .13
French bulldog........................................ 9
German long-haired pointer..................... 10 .5
German pinscher..................................... 11 .38
German Shepard...................                   12
German short haired pointer................... 12
German spitz........................................... 11 .33
German wirehaired pointer..................... 10
Giant schnauzer....................................... 10
Glen of Imaal terrier............................... 10 .42
Golden retriever...................................... 12 .25
Gordon setter........................................... 11 .08
Great Dane............................................... 6 .5
Greenland dog......................................... 8 .46
Greyhound............................................... 9 .08
Griffon Bruxellois................................... 12
Hamiltonstovare...................................... 10 .13
Havanese................................................. 10 .25
Hovawart................................................. 12 .92
Hungarian Puli........................................ 12 .42
Hungarian vizsla..................................... 12 .92
Hungarian wirehaired vizsla................... 9 .83
Irish red & white setter........................... 11 .42
Irish setter................................................ 12
Irish terrier.............................................. 14 .83
Irish water spaniel................................... 9 .33
Irish wolfhound....................................... 7 .04
Italian greyhound.................................... 13 .5
Italian Spinone........................................ 9
Japanese Chin.......................................... 9 .25
Japanese spitz.......................................... 12 .29
Keeshond................................................. 12 .21
Kerry Blue terrier.................................... 11 .5
King Charles spaniel............................... 10 .04
Komondor................................................ 9 .13
Kooikerhondje......................................... 3 .92
Labrador retriever................................... 12 .25
Lakeland terrier....................................... 15 .46
Lancashire heeler.................................... 11 .75
Large Munsterlander............................... 11 .33
Leonberger.............................................. 7 .08
Lhasa apso............................................... 14 .33
Lowchen.................................................. 10
Maltese.................................................... 12 .25
Manchester terrier................................... 12 .83
Maremma sheepdog................................ 10
Mastiff..................................................... 6 .83
Miniature bull terrier.............................. 6 .08
Miniature pinscher.................................. 13
Miniature poodle..................................... 13 .92
Miniature schnauzer................................ 12 .08
Neopolitan mastiff.................................. 2 .33
Newfoundland......................................... 9 .67
Norfolk terrier......................................... 11
Norwegian buhund.................................. 12 .67
Norwegian elkhound............................... 13 .17
Norwich terrier........................................ 13 .38
Nova Scotia duck tolling retriever.......... 8
Old English sheepdog............................. 10 .75
Otterhound............................................... 10 .21
Papillon/butter fly dog............................ 13 .08
Parson Russell terrier.............................. 13
Pekingese................................................. 11 .42
Pharoah hound......................................... 11 .83
Pointer..................................................... 12 .42
Polish lowland sheepdog......................... 9 .58
Pomeranian.............................................. 9 .67
Por tuguese water dog............................. 11 .42
Pug........................................................... 11
Pyrenean mountain dog........................... 9 .58
Pyrenean sheepdog.................................. 5 .79
Rhodesian ridgeback............................... 11
Rottweiler................................................ 8 .92
Saluki/gazellehound................................ 12
Samoyed.................................................. 12 .5
Schipperke............................................... 13
Schnauzer (standard)................................ 11 .96
Scottishterrier.......................................... 10 .25
Sealyhamterrier....................................... 12 .25
Sharpei..................................................... 6 .29
Shetland sheepdog................................... 12 .5
Shiba Inu (Japanese)................................ 7
Shih-tzu................................................... 13.17
Siberian husky.........................................12 .58
Skye terrier.............................................. 11
Soft coated wheaten terrier..................... 12 .5
St Bernard................................................ 7
Staffordshire bull terrier......................... 12 .75
Standard poodle....................................... 12
Sussex spaniel......................................... 11 .13
Swedish vallhund.................................... 14 .42
Tibetan mastiff........................................ 11 .92
Tibetan spaniel........................................ 14 .42
Tibetan terrier......................................... 12 .17
Toy poodle............................................... 14 .63
Weimaraner............................................. 11 .13
Welsh corgi Cardigan............................. 16 .5
Welsh corgi Pembroke............................ 12 .21
Welsh springer spaniel............................ 12 .58
Welsh terrier........................................... 12 .67
West Highland white terrier................... 13
Whippet................................................... 12 .79
Yorkshire terrier...................................... 12 .67




Lucy never did radiation or chemo, she only did the Tippner Protocol. The Tippner Cancer Protocol combines immunotherapy and molecular cancer therapy using off the shelf readily available inexpensive natural substances. Here is her list. She lived more than 5 years after diagnosis by biopsy

I buy most of the stuff from Swanson Vitamins. They are cheaper, in capsules for dosage changes, and carry almost everything I give to Lucy except for the Chinese Herbs Stasis Breaker prescription, Yunnan Bai Yao for bleeding, and the Low Dose Naltrexone prescription.


Posted by Unknown at 1:02 PM

December 5, 2016

December 1, 2016 - more than 5 years after diagnosis - End of Watch


REST IN PEACE MY BEST FRIEND

Lucy had to be put to sleep December 1, 2016. It became an emergency.

She had a very bad bleed that was just not able to be controlled over a day. I tried and tried.

She was fine except couldn't breathe out her nose for the last few months.

But at least 4 full years of 100% remission of zero symptoms, the rest of time just manageable symptoms.

So, in the end the cancer did do her in.

She was 12.5 years old. So almost 90 years old I guess for a dog her size.

It was five and half years since she was diagnosed by lab biopsy.

I am having a very hard time with the grief. She was the most human like dog I have ever had.
 So many parts of my day involved her.  This sucks. So much reminds me all day of her.


I still want to help any and all of you who have questions. It's the least I can do to give back for the very long time she got to stick around.












Lucy never did radiation or chemo, she only did the Tippner Protocol. The Tippner Cancer Protocol combines immunotherapy and molecular cancer therapy using off the shelf readily available inexpensive natural substances. Here is her list. 

I buy most of the stuff from Swanson Vitamins. They are cheaper, in capsules for dosage changes, and carry almost everything I give to Lucy except for the Chinese Herbs Stasis Breaker prescription, and the Low Dose Naltrexone prescription. Here is a $5 off coupon link I found


Posted by Unknown at 1:56 PM

October 7, 2016

Still Lucy October 2016






Still doing ok, not perfect but ok.
I am doing a BBQ today and she will get a cheeseburger with no bun with lettuce and a little beans. No pills except Yunnan and benedryl today. And she gets to lick every single bowl and plate clean.









Lucy never did radiation or chemo, she only did the Tippner Protocol. The Tippner Cancer Protocol combines immunotherapy and molecular cancer therapy using off the shelf readily available inexpensive natural substances. Here is her list. She is past 4 years after diagnosis by biopsy

I buy most of the stuff from Swanson Vitamins. They are cheaper, in capsules for dosage changes, and carry almost everything I give to Lucy except for the Chinese Herbs Stasis Breaker prescription, and the Low Dose Naltrexone prescription. Here is a $5 off coupon link I found


Posted by Unknown at 12:53 PM

June 25, 2016

Low Dose Naltrexone for Pets and Cancer





Dr. Kamau B. Kokayi Interviews Dr. Bihari
September 23, 2003
WBAI in New York City

"Global Medicine Review”
Dr. Kokayi: …the story about Low Dose Naltrexone is really fascinating.  How did you 
get the idea?

Dr. Bihari:  Well, we were treating heroin addicts, and in 1984 a new drug for the 
treatment of addiction came out.  It was called Naltrexone, and it was designed to 
block the heroin “high”and it was a flop.  I used it for a lot of patients, as did most 
addiction doctors across the country.  At 50 milligrams a day, it made people feel 
terrible.  Not that it blocked the heroin so much as it blocked their own endorphins, 
which is a source of our sense of well-being, so that people couldn't sleep.

Dr. Kokayi:  Your own opium, basically.

Dr. Bihari:   Right.  Your own equivalent.  That's what heroin is.  And I knew from 
work that had been done by the National Institute on Drug Abuse in developing the 
drug that it had the ability to trigger the body into making more endorphins, but at the 
high 50 milligram dosage, the dose was too high.  It blocks those endorphins.

About six months later our addicts began dying in large numbers of AIDS.   I ran HIV 
tests on about a hundred addicts, and fifty percent were already HIV positive.  This 
was in 1985; currently it’s eighty eighty-five percent around the country.  And we 
began looking for some way to approach this new disease, with a view to the idea that 
this disease was likely to turn into a worldwide epidemic.

Dr. Kokayi:  That was about the time where people were just being blasted with AZT 
with horrific results.

Dr. Bihari:   Right.  There was nothing else available.  When I discovered that people 
with HIV had less than twenty percent of the normal levels of endorphins, that meant 
that the virus not only kills the immune system cells, it also weakens the whole 
immune system, so that it’s not as able to fight the virus.

We began looking for ways to use this drug to raise endorphins without blocking 
them.  We hired a laboratory scientist to measure endorphin levels.  We’d measure in 
the afternoon, then we'd give the first dose at bedtime that night.  Then we’d measure 
again at the same time the next day; then again at one week, and again at one month.

We found that doses in the range of 1.75 to 4.5 milligrams (which is just a fraction of 
the recommended dosage to addicts) would trigger or jumpstart endorphin production 
during the night.

Except with exercise, endorphins are made only between two and four in the 
morning.  The brain sends a message out to the adrenal and pituitary glands and tells 
them to make endorphins.  Giving a dose three, four, five hours before that, at 
bedtime, is enough to make that message from the brain much stronger.

Dr. Kokayi:  Were you able to document that the levels of endorphins were then 
actually raised?

Dr. Bihari:   The level of endorphins went up by two hundred to three hundred 
percent.  We then started a little foundation and did a placebo-controlled trial in which 
half the patients got the drug and half got sugar pills.  A year later when we broke the 
code, we discovered that people with HIV who took the drug had only an eight percent 
death rate in the year, while people who were on the placebo had a thirty-three percent 
death rate.  And of course they had many more infections and their immune system 
declined.  That was a startling discovery.

Dr. Kokayi:  Now let me jump ahead, because I'm always curious about why this 
therapy hasn't gotten the kind of publicity specifically for this disease.

Dr. Bihari:   Well, at that time there was very little treatment.  AZT came out about ’
87, and as you mentioned, it was not only a flop but made some people sicker.  At the 
time we did the study, there was nothing available.

So I met with doctors in New York and in San Francisco (where the largest number 
of HIV doctors were at that time) and described this drug and how it worked, and 
about forty to fifty doctors on the east and west coast began using it.  Unfortunately, 
they measured effectiveness by whether or not the numbers of the immune system 
cells that are crucial in AIDS -- the CD4 cells -- were rising.  On this drug, CD4 cells 
don't rise in people with AIDS.   As I knew from the study, and have known since, 
they simply stop dropping.  That means you can freeze the disease wherever it is.  And 
if somebody is only mildly immune-suppressed, they stay that way.

Dr. Kokayi:  That's so important…

Dr. Bihari:  It stops progression.  It stops the count from growing.  I have patients 
going back as much as seventeen years who haven't lost an immune system cell in that 
time. They're very healthy.

Dr. Kokayi:  Wow, that needs to be on the evening news.

Dr. Bihari:   The trouble was, we wrote a paper, but couldn’t get it published.  Nobody 
understood the concept.

Dr. Kokayi:   You’re using the dose homeopathically.  You’re using it not for the effect 
that the medicine has on the person, but for the body’s reaction to the medicine.

Dr. Bihari:  It strengthens the body’s own defenses.   Rather than directly attacking, 
the way antibiotics attack bacteria, or the way chemotherapy tries to attack cancer 
cells, or the way anti-viral drugs attack viruses, the purpose of this is to take a weak 
defense (which people with AIDS or cancer have), and strengthen it so that the body 
can fight the disease more effectively.

Dr. Kokayi:   I've often made the point that therapies like acupuncture, therapies that 
are foreign to the cultural mindset of doctors and the American public, these therapies 
can be effective,  but they won’t be included or in mainstream medicine because the 
concept is so foreign.

Dr. Bihari:   It's a different model of understanding the body -- how it works and how 
disease works.  I think eventually there will be changes in the paradigm of the way we 
think about diseases, and it's going to be a struggle.   But I think oncologists in 
particular are getting more and more frustrated with the failure of chemotherapy.

Dr. Kokayi:  Well, about time.

Dr. Bihari:   The people I talk to at the National Cancer Institute, and the Food and 
Drug Administration, are very negative.   All they get from drug companies are 
proposals to test new, more toxic chemotherapies, and they’re really looking very hard 
for non-toxic ways of modifying the behavior of the cancer cells so that they stop the 
cancer from growing.

Dr. Kokayi:   Over the years have you had to modify what you were actually doing 
with Naltrexone?  Or is the initial model impetus pretty much on point?

Dr. Bihari:  The initial model was pretty much on point.  A small dose at bedtime 
increases endorphin production during the night.  In somebody who has a disease 
which is related to low endorphins, the endorphins go back up to normal by the next 
day.

… [station break] ….

Dr. Kokayi:  … can you tell us about some of the work with Naltrexone and cancer?

Dr. Bihari:    During that year, when we were doing our first AIDS trial, an old friend 
of mine called.   Five years earlier, she’d had Non-Hodgkin's Lymphoma.  It had 
initially responded to chemotherapy, but it had grown back after her husband died.  
Her oncologist refused to treat her, saying it would be resistant to chemo the second 
time.

She knew what I’d been doing, and she called me and said, “Bernie, do you think your 
AIDS drug would help my cancer?”

So I dug around and I found a large body of literature showing that when you give 
endorphins, metenkephalins, beta endorphins and even low dose Naltrexone to mice 
that had human cancer transplanted, that there is about an 80 percent recovery rate.  I 
gave her the drug in the same dose we were using in the AIDS trial.  She had large 
masses in her groin, her neck, her chest, and her abdomen, and they all slowly shrank 
and disappeared over a (inaudible) period.   (Inaudible) taking the drug every night.

Dr. Kokayi:    Wow!  You know, even if that's just an anecdote….

Dr. Bihari:   Yes.

Dr. Kokay:   I mean, everyone who has that disease deserves a chance to see if they’re 
going to be an anecdote as well.

Dr. Bihari:    It was actually her idea.  She stayed on the drug, and died about eight 
years later, in her late seventies, of her third heart attack, which was unrelated.

Then I was in Paris the following summer, presenting a paper at an AIDS conference, 
and I met a woman who had a cancer called malignant melanoma.  It starts in the skin, 
and in her case it had spread to the brain.  She had four large brain tumors.  The 
oncologist told her family that she had perhaps three months to live.  When I got back 
to New York, I shipped her the drug from a pharmacy that was making it for our 
study.  She started on it, and her neurological symptoms from the tumors in her brain 
slowly disappeared.  Seven or eight months later she went back to the oncologist, had 
a cat scan of the brain done, and the tumors were gone.

Dr. Kokayi:   Fantastic.

Dr. Bihari:    That was eighteen years ago, and she stayed on it.

Dr. Kokayi:    This is such a non-toxic, simple [inaudible].

Dr. Bihari:    There are absolutely no side effects.  I continued doing a lot of the AIDS 
work, but the last four or five years I've gotten much more interested in other uses.  
We stumbled on the fact, also by chance, that the drug works very well for almost all, 
if not all, of the autoimmune diseases like multiple sclerosis, rheumatoid arthritis, 
lupus, sarcoidosis, and --

Dr. Kokayi:   When you say “it works”, what actually happens?  What's been your 
experience?

Dr. Bihari:    Well, what happens is that the disease activity stops, as long as people 
stay on it.   If they have damage to the brain and spinal cord with multiple sclerosis, 
that doesn't disappear, because that’s due to scarring, but they stop getting new 
attacks.

I've had people on Low Dose Naltrexone for years.  The longest is a friend of my 
daughter, who’s been on it for eighteen years and has not had an attack as long as she 
stayed on it.

Dr. Kokayi:    So it’s almost as if it’s up-regulating the endorphin production but 
somehow the endorphins actually block or inhibit the effect of the antibodies from 
attacking the tissue.

Dr. Bihari:    Not directly.  It's more that the autoimmune diseases are beginning to 
look more and more like they’re diseases of endorphin deficiency.  [Inaudible] models 
of all the diseases I mention that can be bred in mice, the endorphin levels are always 
fifteen to twenty percent of normal compared with normal mice.

[Female Voice]  How can you naturally increase endorphin levels?

Dr. Bihari:    There's only three or four ways that I know.  First, Naltrexone increases 
them substantially, two to three hundred percent in people with low levels.  Second, 
aerobic exercise increases them, but not as much.  If you do an hour of exercise four 
or five times a week it will last three, four hours, and that's one of the reasons that 
exercise helps prevent cancer.  A third way, oddly, is acupuncture.  Acupuncture, 
especially when used in treating addicts, increases endorphin levels in the blood and the 
spinal fluid.  And chocolate increases it.

Dr. Kokayi:    [Inaudible] will be glad to hear that.

Female Voice:  [inaudible]  It actually works out, because you’re going to eat your 
chocolate and then run to the gym.

Dr. Bihari:    Chocolate has a substance in it called Phenylalanine, which slows 
endorphins from being broken down in the body.

Dr. Kokayi:    And that's basically an amino acid that we find….

Dr. Bihari:  Yes, that's the food that has it in the largest amount.   And only people with 
a rare disease called [inaudible] can't eat chocolate.

Dr. Kokayi:   So some people will run to the health food store and get Phenylalanine.

Dr. Bihari:     Well, Phenylalanine is helpful if you’re raising your endorphins by other 
means.  Then it keeps them from decaying.  They last much longer. But the crucial 
thing still seems to me to be the Naltrexone.  Over the last five or six years, I’ve 
treated about 420 patients who have various kinds of cancer with low dose 
Naltrexone.   Occasionally, for people who come to me with very advanced cancer, I 
add intravenous metenkephalin, which is an endorphin...  intravenously, three times a 
week.  It improved immune function substantially, and had no side effects, but that's 
generally not needed.

Among the people I’ve treated with Naltrexone for various kinds of cancer, on the 
average the cancer stops growing in about two-thirds.  For half of that group, it      
eventually -- after six, seven, eight months -- goes on to slowly shrink and disappear.

Dr. Kokayi:   And that's about forty percent.

Dr. Bihari:   Higher.

Dr. Kokayi:   Well, it's about forty percent of the total number.

Dr. Bihari:    Sixty-five percent actually benefit and don't go on to
develop [inaudible]. Thirty percent go into remission.

Dr. Kokayi:   That's phenomenal.  I don't think there’s any chemo or radiating 
oncologist with numbers like that.

Dr. Bihari:   There's no downside.  One of the reasons that the war on cancer failed is 
that the oncologists doing the research failed to take into account that chemotherapy 
really wipes out the immune system, which the body needs to fight cancer cells.  So 
they are giving drugs that kill cancer cells, but at the same time weakening the body's 
defense against cancer.  Naltrexone strengthens the body's defense, and the increased 
endorphins kill cancer cells directly.  Also, the immune system when it's strengthened 
kills cancer cells through its natural killer cells.

Dr. Kokayi:    What you’re saying is, that a boost in endorphin levels also activates 
other components of the immune system.

Dr. Bihari:    The endorphins are the hormones centrally involved in regulating the 
immune system.  About 95% of the regulation or orchestration comes from 
endorphins.  People with cancer -- especially adults – have very low natural killer 
cells.  They have a weakened immune system.  I’ve discovered, after seeing such a 
large number of people, that the vast majority of them have experienced major life 
stresses lasting weeks, months to years – anywhere from two to six years before they 
get the cancer.

Dr. Kokayi:    That was one of my other questions.  What really can keep those 
endorphin levels down in the body?

Dr. Bihari:    If a child gets sick -- children are supposed to outlive us -- so if a child 
gets sick and dies, or if you have a very bad marital break-up, or if you discover a 
business partner is embezzling money and it takes a couple of years to straighten 
out…  If you wake up every morning under stress -- really serious stress, not 
everyday stress -- really serious stress, this can lower your endorphin production, and 
it never returns to normal.  So the person then walks around with low endorphins.  
The body makes cancer cells all the time, but usually the immune system kills them as 
they are forming.  But if your endorphin levels are low, then your immune system is 
weak, the cancers grow and you become much more vulnerable.   The same thing 
with exposure to really toxic substances.  

Dr. Kokayi:    Right.  I'm wondering, I'm sure the listening audience would like to get 
an idea.  If you could just run down a list of some of the cancers that you have 
successfully treated, types of cancers that have seemed to respond where the opiate 
levels play a prominent role.

Dr. Bihari:    Well, first one of the things we discovered was that almost all cancers 
have a lot of receptors for endorphins on the cell surface, and that seems to be 
necessary for it to work.  Some of the cancers that respond most dramatically are 
Multiple Myeloma, Lymphoma, Hodgkin's disease, breast cancer, all the cancers of the 
gastrointestinal tract, like pancreatic cancer, non small-cell cancer of the lung, the kind 
associated with smoking.   I've got several patients with tumors that have stopped 
growing; they have no symptoms, and then after a year, year and a half, in about half 
of that group, the tumors start shrinking and disappear.

Dr. Kokayi:   This is lung cancer?

Dr. Bihari:   These are lung cancers due to smoking.

Dr. Kokayi:    Because there's really --

Dr. Bihari:  Very common.

Dr. Kokayi:    It’s very common, but therapeutic effectiveness --

Dr. Bihari:    There's nothing --

Dr. Kokayi:    There's nothing, right --

Dr. Bihari:   My own attitude about chemotherapy in patients I see with cancer, is if 
they have one of those rare cancers that's very sensitive to chemotherapy, like cancer 
of the testicle, I encourage them to do that, to take it, and take Naltrexone afterwards 
to prevent recurrence.   These drugs are licensed to treat cancer.  Naltrexone is not yet 
licensed to treat cancer, although it's a licensed  drug.  It's been on the market for 
nineteen years.  It's use in these low doses is called an “off-label” use.   Any doctor 
can prescribe it.  And growing numbers of oncologists and neurologists in  the country 
are prescribing it.

Dr. Kokayi:    I think it would be interesting you know just to talk a little bit about the 
process … a lot of physicians don't really know about it and it's not talked about. This 
is a big deal.

Dr. Bihari:    Well, I think it could turn out to be a big deal when it’s picked up, if it’s 
picked up.  We set up a web site,  www.ldninfo.org, which brings up about thirty 
pages of written material describing all the diseases, and how they respond, and how  
many cases we have of them.  There's some small trials going on, there's two trials in 
people with Crohn's Disease, which is an autoimmune disease of the small intestine, 
one in Jerusalem, and one in New York.   There's a trial in Israel for multiple 
sclerosis.  The national cancer institute has copies of twenty charts of my patients 
who have agreed to share their charts.  These are people who have done well on 
Naltrexone when nothing else could explain how well they've done.  They intend to 
present them to a committee for recommendations as to whether to invest and test it in 
the network of cancer research.

Dr. Kokayi:    You know, when I think about Africa and AIDS, this is exactly the kind 
of medicine there needs to be there….

Dr. Bihari:   This is perfect.  In fact, we've been working with the largest 
pharmaceutical company in the developing world called (inaudible) in India to get a trial 
going, probably in Africa, in the Republic of South Africa, in which half the HIV 
patients get the drug, half get a placebo, and they should be able to show in about nine 
months, using two to three hundred patients, that this drug stops progression.

Once it does, it will be manufacturable at less than ten dollars per year per person.  
That's been the big problem -- the anti-HIV drugs are so expensive.  The average 
income in Africa is about eighty dollars per year.

Dr. Kokayi:    I can only imagine just the financial stress that you've had to go through 
just to keep this whole project alive.  It's one thing to prescribe things as an individual 
doctor, but to get recognition within the scientific community is a bit difficult.

Dr. Bihari:   It really bothers me when doctors say, “Oh, I can't prescribe that, 
because he hasn't done a placebo-controlled trial.”  That’s a full-time job, for two, 
three years involving eight or nine centers around the country.  I’m working with a 
number of diseases in my office, and a lot of money goes out paying for the website, 
for patents to cover low dose naltexone, and (inaudible) things like that.  It's very 
veryexpensive.  But I can't stop doing it.  My wife and I would love to do some 
traveling -- I think we've earned it -- but I really can't stop until the drug is out there.   
It's as much of a burden as it does a pleasure.

Dr. Kokayi:    I really hope that at least your sharing with our listening audience today 
helps to make people more aware.  People should be clamoring for it.  We’re running 
out of time, but I wanted to go back to the treatment of autoimmune diseases.   I 
always pictured them as the body is attacking its own tissues.  I pictured these 
antibodies actually honing in there.  But you’re saying that, in large measure it’s an 
actual endorphin deficiency.

Dr. Bihari:    It’s an endorphin deficiency which weakens the immune system, so that 
certain cells in the body forget to distinguish between the body tissues and bacteria or 
viruses, so when these cells are activated by an infection they attack the bacteria and 
they attack you.  Restoring the immune function to normal stops that.  So far, the drug 
works dramatically in all the diseases that are labeled autoimmune diseases.

Dr. Kokayi:   And you've treated lupus with this.

Dr. Bihari:   I've treated -- I have two dozen cases of lupus.  I have about the same 
number of people with rheumatoid arthritis.  I have about twenty people with Crohn's 
Disease.  A number of rheumatologists who specialize in these diseases in New York 
are now beginning to use it, because we have cases in common, and they see.

Dr. Kokayi:    Right

Dr. Bihari:   Because they're using cancer drugs

Female Voice:  Dr. Bihari, is this being used with children with ADD?

Dr. Bihari:    I doubt that it would work, knowing the nature of ADD.  I doubt that it 
would work.  It doesn't do everything for everybody.  I don't think it would.

Dr. Kokayi:  Again, going back to the idea of giving a medicine that at a
higher dose  actually blocks the chemical system, but a lower dose actually augments 
it.

Dr. Bihari:    And enhances the body’s defenses -- that's essential.

Dr. Koyayi:   This idea gives the pharmaceutical industry something to do, rather than 
giving people high doses of medication.

Dr. Bihari:    It certainly would.  It will take this drug to be licensed, picked up by a 
pharmaceutical company and tested, licensed, and once it's widely used, then this 
approach to medicine -- every medical researcher will start thinking about it.  It's an 
entirely different approach to the body and illness.



Lucy never did radiation or chemo, she only did the Tippner Protocol. The Tippner Cancer Protocol combines immunotherapy and molecular cancer therapy using off the shelf readily available inexpensive natural substances. Here is her list. She is past 4 years after diagnosis by biopsy

I buy most of the stuff from Swanson Vitamins. They are cheaper, in capsules for dosage changes, and carry almost everything I give to Lucy except for the Chinese Herbs Stasis Breaker prescription, and the Low Dose Naltrexone prescription. Here is a $5 off coupon link I found


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