Can it help Osteosarcoma?

"Gary, my dog  got osteosarcoma in mid November. I have used your protocol for Lucy with some variations. Without you, he would be dead. Instead, he still has a  tumour on his leg but it's smaller and he is happy and mobile. He needs no pain meds. I thank you from the bottom of my heart. The photo is him a couple of days ago. His vet can't believe how well he is doing. He was given just a few weeks to live. We live in Ontario, Canada. Here is a link to our blog on his condition
http://www.greatdaneangels.org/dog-blog/2015/3/24/bone-cancer-remission-in-dogs"

Lucy never did radiation or chemo, she only did the Tippner Protocol. The Tippner Cancer Protocol combines immunotherapy and molecular cancer therapy using off the shelf readily available inexpensive natural substances. Here is her list. She is past 3 years after diagnosis by biopsy

I buy most of the stuff from Swanson Vitamins. They are cheaper, in capsules for dosage changes, and carry almost everything I give to Lucy except for the Chinese Herbs Stasis Breaker prescription, and the Low Dose Naltrexone prescription. Here is a $5 off coupon link I found

Types of Dog Cancers

Squamous Cell Carcinoma:    Cancer that occurs in the mouth, underneath the tongue or along the gums of the middle-aged and older cats. Common signs of squamous cell carcinoma in cats includes difficulty eating, interest in food but not wanting to eat, drooling and odor from the mouth.

Osteosarcoma:    Osteosarcoma is the most common type of bone tumor in dogs. Osteosarcoma begins in the bone but can spread throughout the bloodstream very early in the course of the disease (metastasis).   The most common areas of the body for this cancer to appear are the wrist, shoulder, knee and hip. The first sign of bone cancer is lameness due to pain from the cancer.   Swelling often occurs at the tumor site. 

Transitional Cell Carcinoma – Tumors usually form at the bladder opening and can cause blockage and  painful urinartion. Pets frequently strain while trying to urinate. Transitional Cell Carcinoma can be difficult to diagnose because many of the symptoms such as straining to urinate, blood in the urine or frequent urination are also a symptom of  a urinary tract infection. This can delay the discovery of the cancer, especially since antibiotics can often result in some improvement of symptoms. Thus, at the time of diagnosis, bladder cancer can be fairly far advanced and may have spread to other parts of the body.

Adenocarcinoma:    Anal sac adenocarcinomas are tumors arising from the apocrine glands present on either side of the rectum. These tumors can range greatly in size from a very small mass that can be found only after a rectal examination or a large mass protruding from the rectum. While the tumor appears locally, it is quite common for them to metastasize,  often to the lymph nodes in between the spine and colon. Symptoms vary depending upon the gender of the pet and can include increased thirst, weakness, persistent licking at the site, difficulty defecating, decreased appetite.

Hemangiosarcoma - Most commonly found in the spleen, liver and heart and the prognosis is determined by the location of the disease. The cancer arises from the blood vessels and results in the production of abnormal blood vessels that can be weak and prone to leaking. As the cancer progresses, the cancerous vessels can rupture and results in blood loss. As the spleen is the organ most commonly affected by this type of cancer, rupture can lead to blood loss into the abdomen. This is an emergency situation and can result in weakness and collapse. Many pets with hemangiosarcoma often require a splenectomy.

Mast Cell Tumors - Mast cell tumors are among the most common tumors in dogs and are the most common type of skin cancer found in dogs. The most common location to find mast cell tumors is, by far, the skin, followed by the spleen, liver, and bone marrow. Both normal and cancerous mast cells contain chemicals that can be released into surrounding tissues. When these chemicals (particularly histamine) are released into the normal surrounding body tissues, side effects can include digestive problems (for ex: bleeding ulcers), skin rashes, shortness of breath and other symptoms. Mast cell tumors vary greatly in their size, shape, appearance and texture. The only way to definitely identify them is with a biopsy and pathology report.

Lymphoma - is cancer of the lymphatic tissue. The lymph system is a core part of the body’s immune system. The lymphatic system is an extensive drainage network that defends the body against infections. It is comprised of a network of lymphatic vessels that carry lymph (a clear, watery fluid that contains protein, salts, glucose and other substances) throughout the body. The lymphatic system also serves as a low pressure drainage system that collects interstitial fluid throughout the body and returns it to the bloodstream. The most common sign of lymphoma is a painless enlargement of the lymph nodes.

Ayurvedic herb Triphala for dog cancer

Commonly seen Dog Cancers are:-

1. Skin cancer - Skin tumors are very frequent in older aged dogs, but are less common in cats. Most skin cancer in cats is malignant, but in dogs they are frequently benign. All skin tumors should be examined by the veterinary doctor.
   
   
2. Breast cancer- 50 % of all breast tumors in dogs and eighty five percent of all breast tumors in cats are metastatic. Spaying your pet between six and twelve months of age will very much decrease the risk of breast cancer. Surgery is the treatment of choice for this type of cancer.
   
   
3. Head & Neck cancer  - Cancer of the mouth is widespread in dogs and less frequent in cats. Accumulations on the gums, bleeding, odor or difficult eating are signs to watch for. Many bulges are malignant, so early treatment is essential. Cancer may build up inside the nose of both cats and dogs. Bleeding from the nose, complexity breathing or facial swelling may happen.
   
   
4. Lymphoma – It is a common form of cancer in both dogs and cats. It is differentiated by growth of 1 or many lymph nodes in the body. A virus is the sources for most of these cancers in cats. Chemotherapy is commonly effectual in controlling this type of cancer.
   
   
5. Testicles cancer- these tumors are rare in cats and common in dogs. Many of these cancers are curable with surgery.
   
   
6. Abdominal Tumors – abdominal tumors inside the abdomen are frequent. It is hard to make an early diagnosis. Weight loss and abdominal extension are common signs of these tumors.
   
   
7. Bone cancer- Bone tumors are most frequently seen in large breed dogs and hardly ever in cats. The leg bones, near joints, are the most frequent sites. Persistent lameness and bump of the leg is an early sign of disease.

Ayurvedic Herb Triphala for Dog Cancer

Triphala – triphala is an herbal supplement that has been an herb of choice for treating cancers. Recent researches have supported this fact. Triphala enhances the immunity of the body thus helps in fighting against the cells causing cancer. Triphala since long has been a drug of choice of treating various disorders and diseases.

Triphala is an herbal formulation that is widely used in Ayurveda for the treatment of various ailments ⁽¹⁾. It consists of equal portions of dried and powdered fruits of three medicinal plants: Emblica officinalis, Terminalia chebula, and Terminalia belerica ⁽²⁾. Triphala is used to treat dental caries, anemia, jaundice, constipation, asthma, fever, chronic ulcers, inflammation, obesity and to promote immunity against infections such as pneumonia, tuberculosis, and AIDS.
It demonstrated antioxidant ^{(3) (2)}, anti-inflammatory ⁽⁴⁾, antibacterial ⁽⁵⁾, immunomodulatory ⁽⁶⁾, chondroprotective ⁽⁷⁾, antidiarrhoeal ⁽¹²⁾, and anticancer ^{(8) (1) (9) (13)} properties in vitro. These effects are due to the polyphenols and flavonoids present in its constituents. Triphala also showed hypolipidemic ⁽¹⁰⁾ and enteroprotective effects against methotrexate-induced damage in rats ⁽¹⁴⁾. However, these effects have not been tested in clinical trials.
A small study did not find significant difference between triphala and chlorhexidine mouthwashes when used for prevention of dental caries in children ⁽¹⁵⁾.

Triphala may cause gastrointestinal side effects.

Purported Uses

• Anemia
• Jaundice
• Constipation
• Asthma
• Infections
• Chronic ulcers
• Inflammation
• Obesity
• Hypercholesterolemia
• Cancer

Constituents

• Amla (Emblica officinalis)
• Myrobalan (Terminalia chebula)
• Belleric Myrobalan (Terminalia belerica)

Mechanism of Action

The exact mechanism of action is not known although the polyphenols and flavonoids are thought to be responsible for many of Triphala's effects. Gallic acid, a major polyphenol in Triphala, has antioxidant property ⁽¹¹⁾. Triphala also increased the reactive oxygen species (ROS) in breast cancer cells (MCF-7 and T-47D), resulting in apoptosis ⁽⁸⁾. Terminalia chebula, one of the components of Triphala, was shown to be a potent hyaluronidase and collagenase inhibitor that prevented degradation of cartilage ⁽⁷⁾. Triphala also protected mice from radiation-induced mortality ^{(2) (3)}. Oral administration of Triphala enhanced immune functions in rats ⁽⁶⁾.

1. Possible Adverse Reactions
   Intestinal gas, stomach upset, diarrhea
   
   
2. Herb-Drug Interactions
3. • Cytochrome P450 substrates: Triphala inhibits CYP3A4 and CYP2D6, and can affect the intracellular concentration of drugs metabolized by these enzymes ⁽¹⁶⁾.
   
   
   References

   1. Sandhya T, Lathika KM, Pandey BN, Mishra KP. Potential of traditional ayurvedic formulation, Triphala, as a novel anticancer drug. Cancer Lett 2006;231(2):206-14.
   2. Naik GH, Priyadarsini KI, Bhagirathi RG, et al. In vitro antioxidant studies and free radical reactions of triphala, an ayurvedic formulation and its constituents. Phytother Res 2005;19(7):582-6.
   3. Jagetia GC, Malagi KJ, Baliga MS, et al. Triphala, an ayurvedic rasayana drug, protects mice against radiation-induced lethality by free-radical scavenging. J Altern Complement Med 2004;10(6):971-8.
   4. Rasool M, Sabina EP. Antiinflammatory effect of the Indian Ayurvedic herbal formulation Triphala on adjuvant-induced arthritis in mice. Phytother Res 2007;21(9):889-94.
   5. Kumar MS, Kirubanandan S, Sripriya R. Triphala Promotes Healing of Infected Full-Thickness Dermal Wound. J Surg Res 2007.
   6. Srikumar R, Parthasarathy NJ, Devi SR. Immunomodulatory activity of triphala on neutrophil functions. Biol Pharm Bull 2005;28(8):1398-403.
   7. Sumantran VN, Kulkarni AA, Harsulkar A, et al. Hyaluronidase and collagenase inhibitory activities of the herbal formulation Triphala guggulu. J Biosci 2007;32(4):755-61.
   8. Sandhya T, Mishra KP. Cytotoxic response of breast cancer cell lines, MCF 7 and T 47 D to triphala and its modification by antioxidants. Cancer Lett 2006;238(2):304-13.
   9. Deep G, Dhiman M, Rao AR, Kale RK. Chemopreventive potential of Triphala (a composite Indian drug) on benzo(a)pyrene induced forestomach tumorigenesis in murine tumor model system. J Exp Clin Cancer Res 2005;24(4):555-63.
   10. Saravanan S, Srikumar R, Manikandan S. Hypolipidemic effect of triphala in experimentally induced hypercholesteremic rats. Yakugaku Zasshi 2007;127(2):385-8.
   11. Kaur S, Michael H, Arora S, et al. The in vitro cytotoxic and apoptotic activity of Triphala—an Indian herbal drug. J Ethnopharmacol 2005;97(1):15-20.
   12. Biradar YS, Singh R, Sharma K, et al. Evaluation of anti-diarrhoeal property and acute toxicity of Triphala Mashi, an Ayurvedic formulation. J Herb Pharmacother. 2007;7(3-4):203-12.
   13. Shi Y, Sahu RP, Srivastava SK. Triphala inhibits both in vitro and in vivo xenograft growth of pancreatic tumor cells by inducing apoptosis. BMC Cancer. 2008 Oct 10;8:294.
   14. Nariya M, Shukla V, Jain S, Ravishankar B. Comparison of enteroprotective efficacy of triphala formulations (Indian Herbal Drug) on methotrexate-induced small intestinal damage in rats. Phytother Res. 2009 Aug;23(8):1092-8.
   15. Tandon S, Gupta K, Rao S, Malagi KJ. Effect of Triphala mouthwash on the caries status. Int J Ayurveda Res. 2010 Apr;1(2):93-9.
   16. Ponnusankar S, Pandit S, Babu R, Bandyopadhyay A, Mukherjee PK. Cytochrome P450 inhibitory potential of Triphala—a Rasayana from Ayurveda. J Ethnopharmacol. 2011 Jan 7;133(1):120-5.

   
   
   
   
   
   

      

   Triphala is an Indian ayurvedic herb. Recently, it has been investigated for use as an anti-carcinogen. Triphala has also shown antioxidant and immune-enhancing benefits in test tube studies. It contains several compounds that are responsible for most of its therapeutic effects, including cancer prevention. If you have cancer, you should first consult with your doctor before taking triphala.

   Anti-proliferate Effect

   In a 2005 study conducted by G. Deep and colleagues at the Jawaharlal Nehru University in India, triphala has shown to help protect against the development of tumors in mice. The results of their studies have been published in the December 2005 issue of "Journal of Experimental & Clinical Cancer Research." It was found that the anti-proliferate effect of triphala is likely related to apoptosis, or programmed cell death.

   Antioxidant Activity

   Triphala is a rich source of natural antioxidants called polyphenols. Antioxidants inhibit the formation of free radicals, or unstable oxygen molecules, which cause oxidative damage to biomolecules such as lipids, proteins and nuclei acids, impairing normal cell functions. Cellular damage caused by free radicals contributes to increased susceptibility for cellular mutations eventually resulting in the initiation of cancer, the Memorial Sloan-Kettering Cancer Center notes.

   Breast Cancer

   T. Sandhya and colleagues at the Bhabha Atomic Research Center in India examined the effects of aqueous extracts of triphala on the growth and invasion of breast cancer cells. The results, published in the journal "Cancer Letters" in 2006, showed that triphala significantly decreased the growth of MCF-7 breast cancer cells. The analysis of this experiment further suggests that triphala extract might exert its anti-cancer effect by inducing apoptosis.

   Pancreatic Cancer

   Triphala induces apoptosis in human pancreatic cancer cells in vivo in the xenograft models. Scientists at the Texas Tech University Health Sciences Center reveal that triphala activates reactive oxygen species production. Because an accumulation of reactive oxygen species can lead to apoptotic cell death, triphala might inhibit pancreatic cancer cell growth, says Y. Shi, Ph.D., a professor of pharmaceutical sciences and cancer biology center at the Texas Tech University. The results of this experiment were first published in the "BMC Cancer" journal in October 2008.

   Triphala Research study
   Potential of traditional ayurvedic formulation, Triphala, as a novel anticancer drug.
   Cancer Lett. 2005;

   The cytotoxic effects of aqueous extract of Triphala, an ayurvedic formulation, were investigated on human breast cancer cell line (MCF-7) and a transplantable mouse thymic lymphoma (barcl-95). The viability of treated cells was found to decrease with the increasing concentrations of Triphala. On the other hand, treatment of normal breast epithelial cells, MCF-10 F, human peripheral blood mononuclear cells, mouse liver and spleen cells, with similar concentrations of Triphala did not affect their cytotoxicity significantly. The drug treatment was found to induce apoptosis in MCF-7 and barcl-95 cells in vitro as determined by annexin-V fluorescence and proportion of apoptotic cells was found dependent on Triphala concentration. MCF-7 cells treated with Triphala when subjected to single cell gel electrophoresis, revealed a pattern of DNA damage, characteristic of apoptosis. Studies on Triphala treated MCF-7 and barcl-95 cells showed significant increase in intracellular reactive oxygen species (ROS) in a concentration dependent manner. ROS increase was, however, found to be insignificant in MCF-10 F as well as in murine spleen and liver normal cells. In vivo, direct oral feeding of Triphala to mice (40mg/kg body weight) transplanted with barcl-95 produced significant reduction in tumor growth as evaluated by tumor volume measurement. It was also found that apoptosis was significantly higher in the excised tumor tissue of Triphala fed mice as compared to the control, suggesting the involvement of apoptosis in tumor growth reduction. These results suggest that Triphala possessed ability to induce cytotoxicity in tumor cells but spared the normal cells. The differential effect of Triphala on normal and tumor cells seems to be related to its ability to evoke differential response in intracellular ROS generation. The differential response of normal and tumor cells to Triphala in vitro and the substantial regression of transplanted tumor in mice fed with Triphala points to its potential use as an anticancer drug for clinical treatment.

The in vitro cytotoxic and apoptotic activity of Triphala--an Indian herbal drug.
J Ethnopharmacol. 2005.
A study on cytotoxic effect of acetone extract of Triphal" whose antimutagenicity has already been tested. The in vitro antimutagenic activity of Triphala --an Indian herbal drug. Food Chemistry and Toxicology 40, 47-54) was extended to test its cytotoxic effects on cancer cell-lines using Shionogi 115 (S115) and MCF-7 breast cancer cells and PC-3 and DU-145 prostate cancer cells as models. The results revealed that acetone extract of "Triphala" showed a significant cytotoxic effect on these cancer cell-lines and the effect was similar on all cancer cell lines used in this study. The major phenolic compounds in the most potent acetone extracts were isolated and purified. Structural analysis was conducted using spectroscopic techniques including mass spectroscopy, nuclear magnetic resonance (NMR) and infrared (IR) which showed gallic acid as the major component. The suppression of the growth of cancer cells in cytotoxic assays may be due to the gallic acid-a major polyphenol observed in Triphala.

1. 
   
   
   Read more: http://www.livestrong.com/article/494576-triphala-cancer/#ixzz2FYrd52eV

   
   
   
   

   • "BMC Cancer"; Triphala Inhibits both in vitro and in vivo Xenograft Growth of Pancreatic Tumor Cells by Inducing Apoptosis; Y. Shi; Oct. 2008
   • "Journal of Experimental & Clinical Cancer Research"; Chemopreventive Potential of Triphala (a Composite Indian Drug) on Benzo(a)pyrene Induced Forestomach Tumorigenesis in Murine Tumor Model System; G. Deep, et al.; Dec. 2005
   • "Cancer Letters"; Potential of Traditional Ayurvedic Formulation, Triphala, as a Novel Anticancer Drug; T. Sandhya, et al.; Jan. 2006
   • Memorial Sloan-Kettering Cancer Center; Triphala

   
   References

An Indian herbal remedy could one day be used to help fight pancreatic cancer, scientists hope.
A team at the University of Pittsburgh Cancer Institute found extracts of triphala slowed the growth of human pancreatic tumours grafted onto mice.
The findings, presented at the annual meeting of the American Association for Cancer Research, offer hope that one day a treatment might be developed.
But experts have warned the research is still at a very early stage.

Triphala triggered the cancerous cells to die off and significantly reduced the size of the tumours Professor Sanjay K Srivastava

Triphala is a herbal preparation used in the traditional Indian medicine system Ayurveda.
It contains the dried and powdered fruits of three plants, and it is said to ease intestinal-related disorders, promoting good digestion.


Anti-cancer properties
Previous studies have shown triphala to have an anti-cancer activity in cell cultures, and the new research found this effect also worked in mice fed the herb preparation, without damaging normal pancreatic cells.
The team fed mice grafted with human pancreatic tumours a triphala solution five days per week.
After four weeks they compared the tumour size and proteins contents of the tumours with those of a control group of mice that had not received the triphala.
They found that the tumours in triphala-treated mice were half the size of those in the untreated mice.
The also found the treated mice tumour cells had higher levels of proteins associated with apoptosis - the process by the which the body normally disposes of damaged, old of unneeded cells.
In cancer cells this process is often faulty, allowing the tumours to divide rapidly without any cells dying.


Professor Srivastava said: "Triphala triggered the cancerous cells to die off and significantly reduced the size of the tumours without causing any toxic side effects."
Further testing revealed that triphala had also activated tumour-suppressor genes, but did not negatively affect normal pancreatic cells.
Professor Srivastava said: "Our results demonstrate that triphala has strong anti-cancer properties given its ability to induce apoptosis in pancreatic cancer cells without damaging normal pancreatic cells.
 "With follow-up studies, we hope to demonstrate its potential use as a novel agent for the prevention and treatment of pancreatic cancer." 


http://www.ncbi.nlm.nih.gov/pubmed/21138390

Triphala, Ayurvedic formulation for treating and preventing cancer: a review.

Source

Research and Development, Father Muller Medical College, Mangalore, Kankanady, Karnataka, India. 

Abstract

BACKGROUND: Triphala (Sanskrit tri = three and phala = fruits), composed of the three medicinal fruits Phyllanthus emblica L. or Emblica officinalis Gaertn., Terminalia chebula Retz., and Terminalia belerica Retz. is an important herbal preparation in the traditional Indian system of medicine, Ayurveda. Triphala is an antioxidant-rich herbal formulation and possesses diverse beneficial properties. It is a widely prescribed Ayurvedic drug and is used as a colon cleanser, digestive, diuretic, and laxative. Cancer is a major cause of death, and globally studies are being conducted to prevent cancer or to develop effective nontoxic therapeutic agents. Experimental studies in the past decade have shown that Triphala is useful in the prevention of cancer and that it also possesses antineoplastic, radioprotective and chemoprotective effects

Triphala churna is a mild laxative, which cleanses and tonifies the gastro-intestinal tract. It is made from the three most important herbs in Ayurveda : Amalaki (Emblica Officinalis), Haritaki (Terminalia Chebula), and Vibhitaki (Terminalia Bellirica). Triphala is known as a cleaning agent, including a blood cleanser. The herb also has a high nutritional value, including high levels of vitamin C. Because of its high vitamin content, Triphala is often used as a food supplement like vitamins are in Western countries. In fact, the benefits of this herb are so well known that a well known Indian saying goes like this: "You do not have a mother? Don't worry, as long as you have Triphala in your life!".In recent years, a number of research studies have found new uses for this herb, including treatment for various forms of cancer. It is also found to have high antioxidant qualities, and is even useful for treatment against noise and stress induced conditions.^[3]

Benefits of Triphala Churna ^{[4][5][6]
(TRIPHALA CONTAINS THE BELOW HERBS)}
Amalaki or Amla (Emblica Officinalis)

• Is a fruit rich in vitamin C that builds immunity and an effective antioxidant that removes harmful toxins from the body.
• Amla helps to strengthen and nourish the lungs and the respiratory tract by removing mucus
• Vitamin C in Amla helps to maintain good reproductive health in both males and females, in whom it further helps to regulate menstrual cycles.
• Amla induces iron that aids blood circulation and maintains proper functioning of the heart.
• Its detox function helps in the formation of fresh tissues leading to a glowing skin.

Vibhitaki (Terminalia Bellirica)

• Vibhitaki acts as a blood purifier and curbs haemorrhage
• It is an internal cleanser removing harmful toxins and excess fats out of the body
• Its anti-viral and anti-bacterial abilities nurtures voice quality and improves eyesight
• Hair roots are strengthened and it enriches hair colour.

Haritaki (Terminalia Chebula)

• Haritaki has five rasas , or tastes, being sweet, sour, salty, bitter, pungentand astringent
• It stimulates the functioning of the digestive system and sensory organs
• It is an effective in combating piles, anaemia, gastro-intestinal problems and gall stones

One of the commonest and cheapest of Indian ayurvedic medical formulations - Triphala - is now emerging as one of the most potent anticancer agents.
This is the conclusion of scientists from a number of prominent research institutions in India as well as abroad, confirming some of the earlier studies conducted at Amala Cancer Research Center by Dr Ramadas Kuttan and associates since 2002.
In a study entitled ‘Potential of traditional ayurvedic formulation, Triphala, as a novel anticancer drug’ published in the January 2006 issue of Cancer Letters, scientists at the Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, found that Triphala “possessed the ability to induce cytotoxicity (cell death) in tumor cells but spared the normal cells.
The scientists explain that the differential effect of Triphala on normal and tumor cells seems to be related to its ability to evoke differential response in intracellular ROS (Reactive Oxygen Species) generation. Conclusion: “The differential response of normal and tumor cells to Triphala in vitro and the substantial regression of transplanted tumor in mice fed with Triphala points to its potential use as an anticancer drug for clinical treatment.
Similarly, a December 2005 report in the Journal of Experimental and Clinical Cancer Research from the Radiation and Cancer Biology Laboratory at Jawaharlal Nehru University noted that Triphala was effective in reducing tumor incidences and increasing the antioxidant status of animals. The authors claim that theirs is “probably the first report on cancer chemopreventive potential of Triphala.” They also note “It was important to observe that Triphala was more effective in reducing tumor incidences compared to its individual constituents.
Another report from the Department of Botanical Sciences, Guru Nanak Dev University, Amritsar, found that "Triphala" showed a significant cytotoxic effect on cancer cell-lines and the effect was similar on all cancer cell lines used in this study.” The results, reported in the Journal of Ethnopharmacology in February 2005, reveal that the results may be due to the action of gallic acid-a major polyphenol observed in "Triphala". The same authors had previously reported that Triphala “had promising antimutagenic/anticarcinogenic potential. In February 2006, scientists from the Dr. A.L. Mudaliar Post-Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, reported supplementation with Triphala prevents the noise-stress induced changes in the antioxidant as well as cell-mediated immune response in rats. What this means is that Triphala is an anti stress agent. This study concludes that Triphala restores the noise-stress induced changes because of its antioxidant properties.
Antioxidant studies conducted at The Radiation Chemistry and Chemical Dynamics Division, Bhabha Atomic Research Centre in Trombay revealed that all three constituents of triphala are active and they exhibit slightly different activities under different conditions and the mixture, triphala, is expected to be more efficient due to the combined activity of the individual components. The findings were reported in the July 2005 issue of Phytotherapy Research. Two months later, scientists from BARC reported on the radio-protective ability of a component of Triphala.
Similar results were also reported from Kasturba Medical College, Manipal, in the Journal of Alternative and Complementary Medicine, when scientists claimed that “Triphala, an ayurvedic rasayana drug, protects mice against radiation-induced lethality by free-radical scavenging.” They concluded that “Triphala provided protection against both gastrointestinal and hemopoetic death.
In Phytotherapy Research, July 2004, scientists from Kasturba Medical College reported that certain traditional Indian polyherbal crude drugs, including Triphala, may be potent and novel therapeutic agents for scavenging of (Nitrous Oxide) NO, and thereby inhibit the pathological conditions caused by excessive generation of NO and its oxidation product, peroxynitrite. The scientists say these findings may also help to explain, at least in part, the pharmacological activities like rejuvenating, adaptogenic, anti-infection, anti-inflammatory, cardioprotective and neuroprotective activities of these traditional, clinically used non toxic drugs.

Respiratory system

• Respiratory infection - Triphala is an herb that is known for increasing the immunity of the body. Triphala acts as a powerful security checker and does not let any foreign particle to invade in the body and if by chance it gets into body, it strongly acts on it to eradicate that particle thereby protecting our body with its harmful after effects.
• Cough and cold – as mentioned earlier also that Triphala is very supportive in curbing any kind of infection in the body thereby it is helpful in withholding the conditions like cough and cold as it is also helpful in countering allergies.
• Accumulated mucus in the lungs and chest – as described earlier that Triphala has mucolytic properties thereby it is very helpful in expelling out the extra amount of mucus that some how gets accumulated in the chest and forms the grounds of infection.

• Anti-oxidant – Triphala is one of the powerful antioxidant. Its reference has been found in various ayurvedic texts. Triphala has a unique properties by which it is has the affinity to scavenges free radicals. It is very helpful in retarding the early aging process to make you young for ever. It also fills your body with new energies and enthusiasm that will make you and your body happy.

• Immunity – Triphala is extremely beneficial in increasing the immunity in the body and also helps in fighting any kind of infection that occurs in the body. It is helpful in production of various anti-bodies, T helper cells and lymphocytes that are helpful in fighting against any foreign invasion on our body.

Cancer – recent researches have proven that Triphala is highly effective in treating the cancer. These tests were conducted on mice. It does not let the abnormal division of the cells making them to perform normally. More researches are taking place to prove their effect on humans but it for sure that it has anti cancerous properties that make it a herb for future.

Loss of appetite – Triphala is a herbal formulation that is very effective in normalizing the digestion that is helpful in maintaining the normal amount of hunger desires in the body. It helps in promoting the decreased appetite.

Inflammation – Triphala is highly effective is reducing any kind of edematous growth internally as well as externally in the body and also is helpful in reducing inflammation.

Immuno-modulatory activities of Triphala on neutrophil functioning.

Biol-Pharm-Bull. 2005 Aug; 28(8): 1398-403

Immune activation is an effectual as well as defensive approach against rising infectious diseases. The immuno-modulatory behavior of Triphala (Terminalia chebula: Haritaki, Terminalia belerica: Bhibitaki and Emblica officinalis: Amalaki) were reviewed by testing the a variety of neutrophil functions like adherence, phagocytosis (phagocytic index (P.I) and avidity index (A.I)) and nitro blue tetrazolium (NBT) decrease in albino rats. In latest years much notice is being listening carefully on the immunological changes occur during stress. Noise (100 dB) stress for 4 h/d for 15 d, was engaged to alter the neutrophil purpose. The neutrophil function tests and corticosterone levels were approved out in 8 different groups of animals, namely controlled; Triphala, noise-stress, Triphala noise-stress, and matching immunized groups were used. Sheep RBC (SRBC 5 x 10(9) cells per ml) were used for immunizing the animals that fit in to immunized groups. In Triphala management (1 g/kg/d for 48 d), A.I was found to be considerably improved in the Triphala group, while the residual neutrophil functions and steroid levels were not distorted considerably. Though the neutrophil functions were considerably improved in the Triphala immunized group with a noteworthy reduction in corti-costerone level was seen. On contact to the noise-stress, the neutrophil functions were considerably concealed and followed by an important raise in the corticosterone levels were seen in both the noise-stress and the noise-stress immunized groups. These noise-stress-induced changes were appreciably prohibited by Triphala management in both the Triphala noise-stress and the Triphala noise-stress immunized groups. Hence our investigation has divulged that oral management of Triphala appears to rouse the neutrophil gathering in the immunized rats and stress induced repression in the neutrophil functions were considerably prohibited by Triphala.

This is because this herb (well fruit actually) set consists of the three fruits: Harada, Amla, and Bihara.

Amla is a sour tasting fruit that contains 20 times the amount of vitamin C than citrus fruits such as oranges. This is why this triad of fruits is used as a food supplement. Triphala, however has numerous other benefits besides its high vitamin content.

 The fruit Harada is what regulates your digestive system due to its laxative-like effects. This assists the body in ridding toxins from your liver and improving digestion. Triphala also has circulatory system benefits. Your circulation has the potential to improve when taking this herbal remedy, Additionally, triphala is known to lower blood pressure. According to Organic India, triphala is a blood cleanser, too.
The fruit Harada is an antispasmodic which means that it suppresses muscle spasms. The combination of the three fruits additionally is known to lower cholesterol, assist the body in recovering from stress and act as an anti-inflammatory especially for the stomach. Its anti-inflammatory properties are a result of the quercetin and vitamin C that is within this fruit mixture.

 Triphala is a relatively safe herb. Not many side effects are known to be caused by this antioxidant. Although at high levels it is known to cause diarrhea. 

  In conclusion, flavonoids of the flavone, flavonol, flavanone, and isoflavone classes possess antiproliferative effects in different cancer cell lines. Triphala being rich in these is a potent drug for cancer support. However, it remains for subsequent meticulous studies and investigations to determine which individual polyphenolic molecules can exert the most potent differentiating and growth inhibitory activity in cancer cells. Many people die of cancer without getting proper treatment either because of inaccessibility or unaffordability. So this project also focuses on the contribution of “triphala” in ameliorating the maladies suffered by those inflicted by the dreaded disease. This will help the humanity to eradicate one of the major causes of death. 



I GIVE LUCY 1 TRIPHALA CAPSULE PER DAY I BOUGHT FROM SWANSONVITAMINS.com (I just recently started this in late December 2012)

I also give her Ayurvedic herb Ashwagandha
 - It is also called 'Indian ginseng or winter cherry’ and is one of the most significant Ayurvedic herbs, supplementing with growth, health and energy. Customary use can help to nurture the blood and augment hemoglobin levels. Current studies have established that Ashwagandha has anti-tumor properties and can help to avert or slow the development of cancers. It is an effectual anti-inflammatory and has outstanding calming properties. This herb is often suggested as a tonic to help with recovery after illness.

I give Lucy 1 Ashwagandhaextract capsule per day from swansonvitamins.com

aurum metallicum - gold for cancer treatment?

During the 12th century, the Arabian medical practitioners valued gold highly for treating disorders of the heart. However, after its use by Arabian physicians, gold was not used medicinally till the early part of the 20th century when it was used for curing ailments, such as tuberculosis, and in blood examination for determining the sexually transmitted disease (STD) syphilis. Nowadays, gold is used in conventional medicine to treat rheumatoid arthritis as well as in treating cancer (I need to check this statement data). In effect, homeopathic physicians prescribe aurum met. for people who endure precise clinical complaints that may vary from depression to heart ailments.

In fact, even today physicians of different alternative forms of medicine consider metallic gold to possess healing attributes. In addition, a number of gold salts do possess anti-inflammatory attributes and are used in pharmaceuticals to treat arthritis and other analogous health conditions. Nevertheless, only the salts and radioisotopes of gold have been found to be of pharmaceutical value, since elemental or metallic gold is inactive to all chemicals that it comes across within the body.

I know..... wierd.

But I know for sure that colloidal silver is an antibacterial, antifungal, antiviral, that is non irritating.

I used to put drops of it in Lucy's water for the first few months as a systemic antibiotic. She never had an infection again once I did that.(but I did do other pills as well)

If colloidal gold is similar (that's what this stuff is but in pretty small amounts...) but I also read that gold was and still is used today in the medical field.

It enhances circulation and if it does things like silver does it could start to fall into place. But I am far from saying anything on this yet. Sometimes a bread crumb is just a bread crumb, but sometimes it leads to more and then a path to something. I love Google!

Like chinese medicine using names and things for organs that really have no control over something in the real world what we know today doesn't make it invalid. The herbs still work for the things they said. I am wary of homeopathy in general and there in generally not enough evidence in trials that it works. But dogs don't have bias or need blind testing for stuff. Man, if something worked for somebody I will look into it and try to find some science behind it.

The depression aspect of it could fit because just on my limited research on autism spectrum and bipolar disorders - zinc, magnesium, calcium, and other minerals have to be in sync and in balance and some genetic subtypes do have inferior processing of these due to bad genes. Gold might affect something possibly in that complex process.

Clinical resolution of nasal aspergillosis following therapy with a homeopathic remedy in a dog.

Epstein S, Hardy R.

Source

Wilmington Animal Hospital, Wilmington, DE, USA.

Abstract

A 6 yr old, male, neutered Weimaraner was treated homeopathically for nasal aspergillosis after failing to respond to two treatments of topical (intranasal) clotrimazole and oral amoxicillin trihydrate/clavulanate potassium. Computed tomography, rhinoscopy, fungal culture, and cytology previously confirmed the diagnosis. At presentation for homeopathic treatment, the dog had aggressive left-sided sinusitis and rhinitis with destruction of nasal turbinates and severe bouts of epistaxis. Erosion and depigmentation of the nasal planum were evident. After two treatments with homeopathic aurum metallicum, resolution of clinical signs occurred and clearance of the aspergillosis organisms was documented by computed tomographic scan, rhinoscopy, and histopathology. Homeopathic aurum metallicum may be beneficial in treating cases of canine nasal aspergillosis.

PMID:

22058356

[PubMed - indexed for MEDLINE]

I am wondering if it might be helpful in both cases in this does something to immune system AND help symptoms/healing of nasal destruction. I have to research it lots but it's wild anyway to see something like this in NIHM.

And here is the separate case with photos

http://hpathy.com/veterinary-homeopathy/indiana-a-lucky-dog/

There are three symptoms that are characteristic of aspergillosis (sure sounds like nasal cancer huh misdiagnosis can be common without extra tests) :

• A profuse, clear to opaque discharge from the nostrils that may alternate with episodes of nose bleeding.
• Ulcerations on the external part of the nose.
• Pain or discomfort in the nose or facial area.
One, two, or three of these symptoms are usually present in infections with Aspergillus.
How is aspergillosis diagnosed?
There are several ways to obtain a positive diagnosis of aspergillosis. Swabs of the nasal area that are examined under the microscope are sometimes diagnostic, as are fungal cultures of the area. However, many times these fail to identify the organisms and could also be positive in a dog whose symptoms are not due to the Aspergillus; i.e., many normal animals may have Aspergillus in their nasal passages. Therefore, their use in detecting aspergillosis usually is not recommended. Radiographs (x-rays) of the sinuses and nasal areas often reveal a destruction of the bones in the sinuses.
The use of a small flexible bronchoscope to examine and obtain a biopsy of an infected area inside the nasal cavity or sinus is another effective diagnostic technique. There are also several blood tests including the AGID and ELISA tests that have given fairly accurate results and are a useful diagnostic tool.
Diagnosis is generally made through use of several of these diagnostic techniques. When a dog presents with nasal bleeding and discharge, it is important to differentiate between a tumor and aspergillosis. With a tumor, we rarely see ulcerations on the nose or nasal pain which are trademarks of aspergillosis.


http://www.veterinarypartner.com/Content.plx?P=A&A=2545&S=0&EVetID=228974 Here is a vet link for it. Shows picture.




Here is a person who cured the dog with some supplements
http://canineaspergillosis.blogspot.com/


http://www.holisticanimalmedicines.com/store/sinus_relief_fungal_aspergillus_cryptococcos_bacteria.html place I found with some natural stuff


http://www.naturalpaws.com.au/fungalyeast-skin-infections-usefulinfo-110-false.html info


http://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=14&ved=0CEQQFjADOAo&url=http%3A%2F%2Fahvma.org%2F~ahvma%2Findex.php%3Foption%3Dcom_docman%26task%3Ddoc_download%26gid%3D113%26Itemid%3D134&ei=sfF9UPu2D4TeigKA-IEQ&usg=AFQjCNEGC8T0NxMrRg19_jtEZ-mSUgYitw&sig2=ftMKWI7Tu8lMAwQ0n2vYKQ this is a PDF from the Holistic vet journal about treating it with homeopathy on page 9.

Homeopathic remedy Aurum metallicum 30c is based on symptoms of bone necrosis including facial bone necrosis, head pain, ulcerated nostrils, yellow and malodorous nasal discharge, exostosis of the facial bones, and aggravation from cold weather. (In Murphy’s Repertory, in the Bones Chapter, Bones: decay, face, in–Aurum is the only remedy!)
Indiana never looked back! Over the course of the next few months, with occasional redosing of the remedy and an increase to 200c potency, all of his symptoms resolved: his depression, facial pain, nasal discharge, erosion of his planum nasale (the black “nose” on the dog), and destruction of the bones in his head. After the first homeopathic prescription, Indiana began to play with other dogs, readily using his mouth for the first time in months! Over one year later, Indiana remains a normal dog, with some scarring in his left nostril as the only sign that something had been wrong with him.

So, with just gold and colostrum, this dog got better? Wild.

        

5.0 out of 5 stars Awesome product!!, June 3, 2011

Amazon Verified Purchase

This review is from: Symbiotics Colostrum Plus Powder, 21-Ounce Jar (Health and Beauty)

This stuff has been a God-send to us. It helped our dog overcome nasal aspergillosis, and it helped me overcome my seasonal allergies. We're believers in it!  

         3 of 3 people found the following review helpful

5.0 out of 5 stars My dog and cat both love it!, June 22, 2012

Amazon Verified Purchase

This review is from:  Colostrum Plus

Desperate to avoid chemo therapy for my big ole boy I was turned on to this product by a friend. It enhances an aging immune system and pets will instinctively recognize the colostrum as something they need is what I read. I'm not entirely sure if that was the case or if it was because it smelled like cheese but my dog loves it. He didn't eat for days after his chemo pill that his vet swore was "safe" and would give little to no side effects...grrrr. Like I said, desperate to help him after I poisoned him with "medicine" I ordered this product. Sprinkled a couple of table spoons over his kibble and he ate it. First time in days he ate his kibble. My cat is the pickiest spoiled bratt ever and she even likes it. Then when I was feeling sick (from stress over my dog's illness)and toxic, run down, and fluish I added a tablespoon to my protein shake. It blends well and I didn't taste anything which was a relief because I swear it smells like cheese haha. I did the same thing the next morning and two days later I feel great and have more energy. The benefits from this natural product is amazing. If you google the benefits it does so much. As for my dog, I now have giant 8 year old puppy :)       

At this point I have no idea how this actually works.......  yet

"Nasal Tumor/ Carcinosin 200C

---

My 11 year old Bix has a nasal tumor and she is doing well. I have had a Homeopathic vet percribe Aurum Metallicum LM4, Calcarea Carbonica LM/3, and then Carcinosin every fifth day.
http://www.otherhealth.com/pets-animals/9771-nasal-tumor-carcinosin-200c.html "

Uses

Homeopathic physicians generally prescribe Aurum metallicum (Aurum met.) for individuals suffering from mental ailments, for instance depression that is accompanied by suicidal thoughts. It has been found that individuals who require this homeopathic medication are usually very susceptible to their views and opinions being challenged by others and when such situations occur, they are likely to burst into anger (Bipolar?). At the same time, their appearance turns reddish and they begin to shudder. (it is known that certain metabolic problems with minerals and balancing of neurotransmitters that use those minerals in certain genetic subtypes - hence Lithium as example)

In addition, Aurum met. is also given to augment blood circulation (this may help immune system get at harder to reach places like the nasal cavity...) that may result in blockage of blood in the head or other body parts, for instance, a headache accompanied by evident pounding in the temples.

In homeopathy, Aurum metallicum (Aurum met.) is also an effective medication for treating heart ailments. The heart ailments that are helped by this homeopathic remedy include difficulty in breathing or breathlessness, sporadic pain in the chest behind the breastbone, a sensation that the heart might stop functioning any moment, and a sensation that the blood vessels are hot. In addition, this homeopathic medication is also prescribed for people suffering from liver ailments, for instance jaundice, pain in the bones that is related to loss of bone wherein the bones are extremely susceptible to touch, and even sinus congestion.

Source

The homeopathic remedy Aurum metallicum (Aurum met.) is prepared chemically using gold, which is found in a number of places across the globe, including South Africa, Australia, the United States and Canada.

Comments

From Glen A. - Apr-06-2011

My son had Tourrette's syndrome. (still a neurotransmitter imbalance problem) The very first remedy was aurum met. and within 4 hrs, my son was so much better, it wasn't funny. I then knew that homeopathy was going to cure him Well two yrs later my son is cured, with other remedies that followed. Streptococcus was the last remedy, to have my son cured.



So this could work on cancer AND aspergillus. Some vets even misdiagnose one or the other because they don't get a biopsy. Treatment with all my stuff and this stuff might work either case.

Coenzyme Q10 an adjuvant therapy for cancer

Studies of coenzyme Q₁₀ as an adjuvant therapy for breast cancer

The following has been reported from preclinical studies of coenzyme Q₁₀ and cancer:

• Animal studies found that coenzyme Q₁₀ boosts the immune system and helps the body fight certain infections and types of cancer.
• Coenzyme Q₁₀ helped to protect the hearts of study animals that were given the anticancer drug doxorubicin, an anthracycline that can cause damage to the heart muscle.
• Laboratory and animal studies have shown that analogs of coenzyme Q₁₀ may stop cancer cells from growing.

Coenzyme Q10 is an enzyme made by the body and found in the membranes of many tissues. CoQ10 has effects in stimulating the immune system and works as a strong antioxidant. In animals and people with cancer it has been shown that levels of CoQ10 are lower then in normal individuals. There is some evidence that CoQ10 can increase cancer survival times.

Reduced levels of CoQ10 have been found in animals and people with heart issues. CoQ10 can help to protect the heart, lower blood pressure and help with repair to the heart.

CoQ10 has been shown to reduce cardiotoxicity (toxicity to the heart) in people on the chemotherapy drug doxorubicin (adriamycin).

Small studies have been done on the use of coenzyme Q₁₀ after standard treatment in patients with breast cancer:

• In a study of coenzyme Q₁₀ in 32 breast cancer patients, it was reported that some signs and symptoms of cancer went away in 6 patients. Details were given for only 3 of the 6 patients. The researchers also reported that all the patients in the study used less pain medicine, had improved quality of life, and did not lose weight during treatment.
• In a follow-up study, two patients who had breast cancer remaining after surgery were treated with high doses of coenzyme Q₁₀ for 3 to 4 months. It was reported that after treatment with high-dose coenzyme Q₁₀, the cancer was completely gone in both patients.
• In a third study led by the same researchers, 3 breast cancer patients were given high-dose coenzyme Q₁₀ and followed for 3 to 5 years. The study reported that one patient had complete remission of cancer that had spread to the liver, another had remission of cancer that had spread to the chest wall, and the third had no breast cancer found after surgery.

References

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I give Lucy 1 capsule in her AM meal.

1.