Artemisinin - Wormwood for Cancer

Artemisinin - Wormwood
The next effective treatment I researched and am using on Lucy is Artemisinin (Arte) which is an extract from the wormwood plant.  Artemisinin is used successfully to treat malaria throughout the world.  

Cancer cells have the highest concentration of iron in their cells because they need that iron to stimulate growth, get a good blood supply going and eventually kill the host!  Arte attacks cells with the highest concentration of iron much like the malaria parasite which also contains a lot of iron.

An article appearing in Life Sciences in 2001 by Drs. Singh and Lai at the University of Washington detailed the rapid and complete destruction of a radiation-resistant breast cancer cell line in vitro.  The destruction occurred within 8 hours and had little effect on normal cells. 

Artemisinin has two semi-synthetic derivatives: Artesunate and Artemether.  A paper published in Oncology in 2001 described the cytotoxic effects of Artesunate against a wide variety of cancers including melanomas, breast, ovarian, leukemia and colon cancers. The growth of all of these cancers was inhibited by 50%. 


DOSAGE: I give Lucy my 90 pound Lab with nasal cancer 200mg of Artemisinin Standardized Extract of Wormwood (the whole herb version makes her not want to eat it) 2-3 hours after dinner with her Budwig Diet Cottage Cheese and Flax Oil snack. It MUST be only given away from iron containing foods which would be your normal dog food and and at least 6-8 hours from anti-oxidents. So I put as much anti-oxidents in her morning meal as I can and most immune booster supplements in her PM meal. I buy from Swanson Vitamin the Artemisinin Standardized Extract of Wormwood (the whole herb version makes her not want to eat it) . She is still doing well many months post dx of canine adenocarcinoma nasal cancer.

Here is the 2nd part of the Artemisinin article


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Budwig Diet Plan for Dog Nasal Cancer or any cancer really

The Budwig Diet Plan and Cancer  

This protocol was created by Dr. Johanna Budwig, a bio-chemist, Nobel prize nominee and health practitioner who worked with patients in Germany between 1952 and 2002. During that time, people from all over the world who were suffering from various kinds of cancer, many of them terminal, met with this brilliant woman. She started them on her diet and general protocol and within three or four months, most regained their health.


Doctors who told cancer patients they had to have chemo, radiation or surgery, or told them nothing more could be done for them, giving them only weeks to live, retested them and declared them cancer-free, wrote Dr. Budwig. She claimed her success rate with cancer patients was over 90%.


Cancer epidemiologist John D. Potter of Seattle's Fred Hutchinson Cancer Research Center said, "We're discovering a plethora of bioactive substances in plant foods."..."These compounds seem to interact with every step in the cancer process, mostly slowing, stopping, or reversing them..." Yes, he said that the substances in plant foods can stop or reverse cancer.
One of the keys in the Budwig diet is consuming foods that offer nutrients that help cells absorb oxygen. Dr. Otto Warburg received the Nobel Prize in 1931 for discovering that when cells can no longer absorb oxygen, cancer can develop. Dr. Budwig built on that knowledge and was the first to develop a diet and protocol that restores cells to normal functioning.
At the heart of the Budwig diet is organic, cold pressed, liquid flax seed oil blended with cottage cheese or “quark.” Dr. Budwig discovered that when these two foods are blended together, the sulfurated protein components in the cheese, such as cysteine, bond with the oil, making it more water soluble and easier to digest and metabolize. Consequently, more of the essential fatty acids and electrons in the highly unsaturated flax seed oil reach the cells and have a healing effect on the cell membrane where carcinogens attach themselves. The membrane of each cell is made up of lipids. Flax seed oil can improve this important outer cell lining that is crucial to cell function and division.


Her plan eliminates damaging fats and foods from the diet and replaces them with healing foods and life-saving essential fatty acids. Along with diet, she emphasized the benefits of sunlight and stress reduction. Dr. Budwig had over a 90% success rate with this protocol with all kinds of cancer patients over a 50 year period.  She worked with humans but she herself recommended using the flax oil and cottage cheese for dogs with cancer.  Obviously, her overall diet plan of fresh fruits and veggies is intended for her human patients—our pets can stick with carb free, grain free diets, foods as close to organic as possible and the FLAX OIL/cottage cheese mix once a day.


A main component of the Budwig Protocol is flaxseed oil Dr. Budwig discovered that FLAX OIL supplies the omega-3 and omega-6 oils that are deficient in cancer patients so the cell membrane can aid normal cell replication and attract oxygen to the cell. EFAs are also converted by the body into prostaglandins which regulate kidney function, inflammation response, immune function, keep blood vessels elastic, regulate blood pressure, influence platelet stickiness and properly metabolize cholesterol. A dog’s body can only absorb a limited amount of oil so the instructions below are important for binding the oil to a sulfur protein to allow the resulting water-soluble oil to be absorbed in greater quantities.


Omega 3 fatty acids, soften the cell membranes allowing penetration of supplements and oxygen, making the inner cell less hospitable to cancer. The Budwig protocol should be used in conjunction with Artemisinin, Artemix, Avemar, Oleander, low dose naltrexone, or anything else you are using.  It enhances what you are doing by softening the outer cell membranes to allow penetration of the herbal chemotherapy. 


Purchase organic flax oil—Barleans is a good brand. Get this fresh from the natural foods section of your grocer or health food store. 


There's one really important thing to do with the FLAX OIL to make sure it's maximally absorbable by the body. You need to blend it really well with a high protein dairy product like low fat cottage cheese with pineapple so the oil becomes water soluble. I use a hand held, immersible blender and blend until it looks like cheese cake or cheese with no signs of oil rising to the top, sort of like a smoothie.  But I sometimes just use a fork to mix for a good long time, due to my laziness. And it seems to be working.


The ratio of FLAX OIL to cottage cheese is 1:2 (1 tablespoon of flax oil to 2 tablespoons of cottage cheese). For a large dog (100 pounds) with cancer, your goal is 6 tablespoons of FLAX OIL per day but you should work up to it to avoid causing diarrhea. Start with 3 tablespoons of FLAX OIL per day for a couple weeks then go to 4T for a week, then 5T for a week, then 6T.  For a 50 pound dog, cut the dose in half and for little dogs, cut that in half again.  For prevention, 1 tablespoon of FLAX OIL per 100 pounds should be helpful.

 Tell your vet you are doing this amount of fat, to keep a watch on too much weight gain plus be sure to add this amount of fat over time like it says above so your dogs pancreas doesn't get mad trying to digest these increased fats.  Lucy never got fat.


Cancer loves an acidic environment because it cannot survive in an alkaline environment. Sugar causes acidity, plus it feeds cancer so avoid all sugars.  A grain free diet is best.  Use a high protein diet of cooked foods like eggs and ground turkey and good dog food kibble. Throw some veggies and blueberries so help fill them up and give them more nutrition. Because the protein and fats are going up with anti cancer diets you need to feed kibble in a lower amount and raise the veggies to they don't beg for more for their tummy. Dogs are made for pure protein and medium fat. So people stop with the myths of too high protein. Just make sure they have plenty of fresh water. A discussion of these myths will be blogged later. 
*Unless your dog has diagnosed kidney issues by your vet, feed them what they were built for.  


You can give the Budwig mix as a treat—Lucy is getting this once a day for a snack. She loves it! All I know is I have been doing this for many months now past her biopsy and x-ray proven diagnosis and her symptoms are gone. I am doing other natural stuff like I talk about in this blog, so obviously this is not a perfect study example, but she gets no radiation or chemo and has now lived many months past normally given AND now without symptoms even.


A few vets claim it is not possible for dogs to convert flax seed oil into omega 3 while others make no such claim. They all state, however, that the jury is still out on the dog’s ability to utilize flax seed oil. But Budwig proved it can be absorbed and that it can help. YOU CAN SEE EVERYWHERE THAT THIS STUFF IS GOOD FOR DOGS BECAUSE DOG FOOD MAKERS ARE NOW PUTTING IT IN ALL THE BETTER DOG FOODS AND SUPPLEMENTS FOR DOGS.

Vitamin D and Dog Cancer

Vitamin D shrinks fibroid tumors in rats


NIH-funded study suggests possible treatment for common condition


Treatment with vitamin D reduced the size of uterine fibroids in laboratory rats predisposed to developing the benign tumors, reported researchers funded by the National Institutes of Health.


Uterine fibroids are the most common noncancerous tumors in women of childbearing age. Fibroids grow within and around the wall of the uterus. Thirty percent of women 25 to 44 years of age report fibroid-related symptoms, such as lower back pain, heavy vaginal bleeding or painful menstrual periods. Uterine fibroids also are associated with infertility and such pregnancy complications as miscarriage or preterm labor. Other than surgical removal of the uterus, there are few treatment options for women experiencing severe fibroid-related symptoms and about 200,000 U.S. women undergo the procedure each year. A recent analysis by NIH scientists estimated that the economic cost of fibroids to the United States, in terms of health care expenses and lost productivity, may exceed $34 billion a year.


Fibroids are three to four times more common in African-American women than in white women. Moreover, African-American women are roughly 10 times more likely to be deficient in vitamin D than are white women. In previous research, the study authors found that vitamin D inhibited the growth of human fibroid cells in laboratory cultures.


"The study results provide a promising new lead in the search for a non-surgical treatment for fibroids that doesn't affect fertility," said Louis De Paolo, Ph.D., chief of the Reproductive Sciences Branch of the NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development, which funded the study.


First author Sunil K. Halder, Ph.D., of Meharry Medical College in Nashville conducted the research with Meharry colleagues Chakradhari Sharan, Ph.D., and Ayman Al-Hendy, M.D., Ph.D., and with Kevin G. Osteen, Ph.D., of Vanderbilt University Medical Center, also in Nashville. The findings appeared online in the journal Biology of Reproduction.


For the current study, the researchers tested the vitamin D treatment on a strain of rats genetically predisposed to developing fibroid tumors. After examining the animals and confirming the presence of fibroids in 12 of them, the researchers divided the rats into two groups of six each: those that would receive vitamin D and those that would not.


In the first group, small pumps implanted under the skin delivered a continuous dose of vitamin D for three weeks. The researchers then examined the animals in both groups. Fibroids increased in size in the untreated rats, but, in the rats receiving vitamin D, the tumors had shrunk dramatically. On average, uterine fibroids in the group receiving vitamin D were 75 percent smaller than those in the untreated group.


The amount of vitamin D the rats received each day was equivalent to a human dose of roughly 1,400 international units. The recommended amount of vitamin D for teens and adults age 70 and under is 600 units daily, although up to 4,000 units is considered safe for children over age 9, adults, and for pregnant and breastfeeding females.


"Additional research is needed to confirm vitamin D as a potential treatment for women with uterine fibroids," said Dr. Al-Hendy. "But it is also an essential nutrient for the health of muscle, bone and the immune system, and it is important for everyone to receive an adequate amount of the vitamin."


Fatty fish such as salmon, mackerel and tuna are the best natural sources of the vitamin. Very few foods naturally contain vitamin D. Fortified milk and other fortified foods provide an additional source of the vitamin. Vitamin D is also produced when ultraviolet rays from sunlight strike the skin.


Vitamin D deficiency has been associated with increased risk of colon cancer in epidemiologic and prospective clinical studies. In vitro and in vivo studies demonstrated that 1,25-dihydroxycholecalciferol [1,25(OH)2D3] and its analogs inhibit colon cancer cell proliferation. Few studies have evaluated the effect of vitamin D deficiency on the development and growth of colon cancer. To assess the antiproliferative effects of 25-hydroxyvitamin D [25(OH)D] and 1,25(OH)2D3 in vitro, we cultured MC-26 (a colon cancer cell line) in the presence of 25(OH)D3 and 1,25(OH)2D3 and performed [3H]thymidine incorporation. The proliferation of MC-26 was significantly inhibited by both 25(OH)D3 and 1,25(OH)2D3. To determine the effect of vitamin D deficiency on colon cancer proliferation, Balb/c mice were rendered vitamin D deficient by feeding them a vitamin D–deficient diet for 3 mo. A group of vitamin D–sufficient mice was given the same diet with supplemental vitamin D. The mice were injected with MC-26 colon cancer cells and the tumors were measured daily for 20 d. Vitamin D–sufficient mice had 40% smaller tumors than vitamin D–deficient mice. The tumors were evaluated for mRNA expression of the vitamin D receptor (VDR) and 25-hydroxvitamin D-1α-hydroxylase (1α-OHase) by quantitative RT-PCR. The expression of the mRNA for the VDR and the 1α-OHase was 37- and 6-fold higher, respectively, in the vitamin D–sufficient mice compared with the vitamin D–deficient mice. We conclude that vitamin D deficiency enhances the growth of colon cancer in mice. The tumor expression of VDR and 1α-OHase indicates possible autocrine/paracrine cell growth regulation by vitamin D.


As in herbivores and omnivores, the biosynthesis of vitamin D3 in the skin exposed to ultraviolet (uv) light is generally expected to also occur in the dog and the cat. The purpose of this in vitro study was to measure the concentrations of vitamin D3 and its precursor 7 dehydrocholesterol (7DHC) in dog and cat skin before and after a quantitatively and qualitatively standardized exposure to uv light. The results are compared to those obtained by the same method in the skin of the rat. The efficiency of extracting 7DHC and vitamin D3 from skin was 72 ± 8% and 67 ± 3%, respectively. In dog and cat skin the concentrations of nonesterified 7DHC were below the detection limit of the HPLC system. Therefore, skin extracts were saponified and total 7DHC and vitamin D3 concentrations were measured by normal-phase HPLC. Before irradiation with uv-B light the total concentrations of 7DHC were 1858 ± 183, 1958 ± 204, and 17,620 ± 2345 ng/cm2 skin (mean ± SEM; n = 5) for the dog, the cat, and the rat, respectively. The corresponding concentrations of vitamin D3 were 211 ± 44, 193 ± 18, and 161 ± 32 ng/cm2 skin for the dog, the cat, and the rat, respectively. Irradiation of standard solutions of 7DHC with 0.15 J uv-B light/min resulted in a time-dependent decrease in 7DHC and a concomitant increase in previtamin D3. After exposure of skin to a total of 2.25 J uv-B light no significant changes in concentrations in vitamin D3 were found in extracts of the skin of the dog and the cat, whereas a 40-fold increase in the vitamin D3 concentration occurred in the skin of the rat. It is concluded that in the skin of the dog and the cat only low concentrations of esterified 7DHC are present and that this 7DHC is also inadequately converted to vitamin D3. As shown previously there is no detectable increase in vitamin D3 in the dog exposed to uv irradiation in vivo. Therefore, these low 7DHC concentrations are not caused by high turnover of 7DHC but are due to restricted availability of this vitamin D3 precursor in the skin of the dog. Thus, the dog and the cat are, unlike herbivores and omnivores, not able to synthesize vitamin D3 adequately in the skin and are mainly dependent on its dietary intake, i.e., vitamin D3 is an essential vitamin for the dog and cat.


Vitamin D may help prevent certain cancers, and high doses may enhance chemotherapy, says Rodney Page, director of the Sprecher Institute for Comparative Cancer Research and the Program on Breast Cancer and Environmental Risk Factors, both in the College of Veterinary Medicine at Cornell.

That is why he and colleagues at the Sprecher Institute are collaborating with the Roswell Park Cancer Institute to study the role of vitamin D in cancer in several animal models.

"Vitamin D can affect regulation of many cellular processes associated with cancer development and therapy, including differentiation, proliferation and cell death," said Page.

Page and colleagues also are studying how vitamin D affects chemotherapy in dogs and cats. So far, they have determined that high doses can be safely given to dogs getting chemotherapy and that blood concentrations of vitamin D can be achieved to potentially improve cancer response. They are now planning a follow-up study to determine whether vitamin D improves the outcome in dogs with cancer.


From what I've read, here are foods containing vit D: Shitake mushrooms, herring, sardines, catfish, tuna, Sockeye salmon, eggs. Sunlight.


An acupuncture vet (a holistic one) said many holistic vets have been using Vitamin D injections for years on cancer dogs.


Vitamin D is a member of the fat-soluble class of vitamins, meaning that it is stored in the liver and fatty tissues of the body. The recommended minimum daily dose is 227 IU per pound of consumed dry dog food. This can be obtained through exposure to sunshine (converted into Vitamin D in the upper layers of the skin) and consumption of dairy products and fish liver oil and, of course, a good commercial dog food.
Vitamin D regulates the calcium:phosphorous balance in the body. It stimulates kidney retention of calcium and is vitally important to bone formation and nerve and muscle control.


"As a steroid hormone that regulates mineral homeostasis and bone metabolism, 1α, 25-dihydroxycholecalciferol also has broad spectrum anti-tumor activities as supported by numerous epidemiological and experimental studies. It potentiates the anti-tumor activities of multiple chemotherapeutics agents including DNA-damaging agents cisplatin, carboplatin and doxorubicin; antimetabolites 5-fluorouracil, cytarabine, hydroxyurea, cytarabine and gemcitabine; and microtubule-disturbing agents paclitaxel and docetaxel. Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms. It enhances the cytotoxic effects of gamma irradiation and certain antioxidants and naturally derived compounds. IT has been used in a number of clinical trials and it is important to note that sufficient dose and exposure to is critical to achieve anti-tumor effect. Several trials have demonstrated that safe and feasible to administer high doses through intermittent regimen."



"Efficacy of Vitamin D (Calcitriol) for Treatment of Canine Mast Cell Tumors." Dr. Kenneth Rassnick

Mast cell tumors are common skin tumors in dogs. There is a tremendous need to develop effective therapies for this cancer in dogs. Calcitriol is the active form of vitamin D, and the potential for calcitriol as an anti-cancer agent has been demonstrated in laboratory studies. Clinical trials of calcitriol in people with cancer are underway.

Dr. Rassnick and his colleagues have established a safe oral dosing regimen for calcitriol in dogs and have already observed regression of an advanced mast cell tumor in a dog treated with calcitriol. The objectives of this proposal are to investigate the anti-tumor activity of calcitriol against a canine mast cell tumor cell line. Additionally, they will conduct a clinical trial using oral calcitriol to treat dogs with naturally occurring mast cell tumors. They expect that the results of this research will show that calcitriol is an effective treatment for mast cell tumors in dogs. These results will significantly impact the management of dogs with mast cell tumors as they will lead to future use of calcitriol as a palliative and/or standard therapy in dogs with this disease.


VITAMIN D is also considered to be a hormone. It is not only found in food, but also sunlight. It helps with the metabolism of calcium and phosphorus in the body by increasing absorption of these in the intestines. A deficiency of this vitamin in puppies can result in rickets, stunted growth, delayed tooth development and bone deformities. The daily intake for a dog would be 100 IU or less for a small dog, 200 IU for a medium sized dog and 400 IU for a large dog. Food sources for this vitamin include fatty saltwater fish, fish liver oils and fortified dairy products. Sunlight also provides some vitamin D.




I give Lucy my 90# Lab with cancer about 2000IU in one of her meals on random days of the week. 

Dog Cancer Omega 3 Fish Oil

I give Lucy much more fat than anyone would think to give. She gets at least 8-10gram per day. 8 fish pills (4 at each meal) plus 1 tablespoon of Flax on Cottage Cheese which might be about 2grams.


Here some quotes around the web:

"Fish oil at 1000 mg per 20 lbs of dog each day is a recommended minimum dosage supplement for dogs with cancer"
"This is in addition to the Flax oil in the cottage cheese."


"Fats:
Not only do dogs have metabolism differences with carbohydrates, but they also
show abnormalities in lipid metabolism. These abnormalities contribute to
immune suppression. Malignant cells cannot use lipids for energy, so Dr. Ogilvie
suggests adding much more fat to a dogs diet, and in particular, the essential
fatty acid, Omega-3. He not only states that Omega-3 fatty acids will help a dog
with energy, but can actually help stop tumor growth.
Foods rich in Omega-3 include Flaxseed Oil, salmon and other cold water fishes.
He does suggest to limit the amount of Omega-6 fatty acids, as it has proven in
his tests that these oils can cause cancer to grow faster. Those oils would
include GLA's, or primrose oils, borage oil and black current oil."

"Many vets will recommend Hill’s n/d for cancer patients because it is clinically proven to improve outcomes, although the clinical results are only confirmed for lymphoma, nasal and oral tumors. Hill’s n/d is a prescription diet available through any veterinarian. It has what is thought to be an optimal ratio of proteins (37%), carbs (21%) and fats (32%) as well as additional Omega 3 Fatty Acids in the form of fish oil (min 7%) and an amino acid called Arginine (3%).( I GIVE 900mg of that)

There are some drawbacks to Hill’s n/d though, that lead many pet guardians to choose other options. First, it is a relatively expensive diet, especially for larger breeds. Secondly, it only comes in canned formula because of its high fat content. As a result, some picky eaters may not like the taste of it if they have been raised on kibble all their lives. Third, and most importantly to those who wish to feed their dog as naturally as possible, the quality of the ingredients in n/d are not ideal, as animal by-products are used to produce this food. "


A Vet blog:
"If your loved dog has a cancer at this time, you want to get as much omega 3 in him or her as possible. Start slowly and work your way up to large amounts over about 2 weeks to avoid an upset stomach. Give with food. For a dog about 60 lbs, you want about 18 grams of good quality fish oil containing omega 3′s. This usually means about 15-20 of the typical capsules daily, which is a large amount! For double strength caps, halve the dose. Adjust up or down for the size of your dog. The capsules can be popped and the oil mixed in food if your dog resists eating the capsules by themselves. Watch for digestive upset (vomiting, diarrhea, loss of appetite), and if so, stop and then later start with lower doses increased more slowly.
If your loved dog is not diagnosed with cancer and is on typical commercial food, I would have you begin an omega 3 fatty acid supplement at lower doses than those dogs with cancer. For a 60 lb dog, my opinion is a standard supplemental dose of roughly 4-6 grams of omega 3-containing capsules daily. Remember to start with low doses than work up over 2 weeks. "

Lucy Nasal Cancer Status Update

Well, it's 28 days and counting to the 1 year anniversary of Lucy's nasal cancer biopsy lab double tested and vet and scan diagnosed Canine Adenocarcinoma nasal cancer positive result. 



She was given 4-6 months. She had all the symptoms too. Man, the blood, the snot, the teary eye, the infections. This cancer was a horror show.


Guess what? At this point, still no sign of cancer anymore, no symptoms at all. Since the end of July of 2011 she has went into and stayed in remission doing all stuff I post on here and am still doing.


Ok, keep fingers crossed. 


Keep researching, keep making that poor dog take endless pills and herbs. But she doesn't seem to mind them that much. She's not fussy. Man that helps.


THANKS TO ALL THE HIGHER POWERS AND TO ALL THE POSTED RESEARCH OF EVERYONE ON THE WEB! THANKS TO ALL WHO MAKE DISCUSSION GROUPS AND WEBSITES DEDICATED TO DOG CANCER!
THANKS TO RESEARCH AT UNIVERSITIES, THANKS TO HOLISTIC VETS, THANKS TO 4000 YEARS OF CHINESE AND INDIAN AYURVEDIC HERBAL USE.  THANKS TO SUPPLEMENT RESEARCH. THANKS TO MEDICAL RESEARCH. 


EVERYONE - USE E: ALL OF THE ABOVE!