| Table 1: Causes, Diagnosis and Treatment of Vomiting in Dogs |
| Cause | Example | Dogs Most at Risk | Symptoms | Diagnosis | Treatment |
| Gastric dilitation and volvulus (bloat) | | Deep chested, large breed dogs | Vomiting, retching, bloated abdomen | History; physical exam; radiographs | Surgery; supportive care; this is an emergency condition and requires immediate treatment |
| Benign gastric outflow obstruction | Pyloric stenosis, polyps | Boxers, Bulldogs, Boston Terriers, young animals | Intermittent vomiting, weight loss, dehydration | History, physical exam, radiographs, endoscopy | Surgery to correct outflow obstruction; antacids |
| Diet change | Changing dog food brand or feeding a high fat meal | Those switching from a consistent diet | Usually no other signs of being ill | History and physical exam; tests (eg., fecal flotation) to rule out other causes | Withhold food as needed then switch to bland diet and then slowly back to normal diet |
| Food intolerance or sensitivity | Sensitivity to or inability to digest or absorb certain foods such as milk or gluten | Gluten hypersensitivity: Irish setters and soft coated Wheaton terriers | Sudden onset of diarrhea, sometimes with gas | Monitor response to removing ingredient from diet and then adding it again (food trial) | Withhold food as needed then switch to diet without the offending ingredient |
| Intestinal parasites | Hookworms | Young dogs | Diarrhea, vomiting, weakness, pale gums, dehydration, anemia, swollen abdomen, black and tarry stools | Fecal flotation exam | Multiple treatments with appropriate wormer; decontaminate environment; supportive care |
| Giardia | Usually young animals or those who are immunosuppressed | Mild to severe soft diarrhea with mucus and a bad odor; weight loss, abdominal pain and vomiting; often intermittent | ELISA test on feces; fecal flotation exam or microscopic exam of feces; difficult to diagnose - often need multiple samples over several days | Metronidazole, albendazole or febantel; bathing and sanitation to remove Giardia from coat and environment. Reinfection commonly occurs. |
| Garbage ingestion | | Those left unattended or unsupervised | Diarrhea, vomiting | History and physical exam | Withhold food as needed then switch to bland diet and then slowly back to normal diet |
| Bacterial infection | Salmonella, E. coli, Clostridia | Young kenneled dogs or those who are immunosuppressed | Mild to severe bloody diarrhea with loss of appetite, depression, fever and vomiting | Fecal culture and sensitivity; microscopic exam of feces | Antibiotics; intravenous fluids and supportive care in more serious conditions |
| Viral infections | Parvovirus | Young dogs who have not received full series of parvo vaccinations | Loss of appetite, fever, depression, vomiting, diarrhea, dehydration, abdominal pain | History, physical exam, fecal test for presence of parvovirus, white blood cell count | Intravenous fluids, antibiotics to prevent secondary bacterial infection, withhold food and water |
| Distemper | Young dogs who have not received full series of distemper vaccinations | Loss of appetite, fever, depression, cough, vomiting, diarrhea; later see neurological signs | History and physical exam; tests (eg., fecal flotation) to rule out other causes; viral testing on blood, urine, or other body fluids | Intravenous fluids if dehydrated; antibiotics to prevent secondary bacterial infections. Prognosis is poor |
| Coronavirus | More severe in very young dogs, especially those with other intestinal diseases; more of a problem in animal shelters or where there are large numbers of stressed dogs | Diarrhea, poor appetite, lethargy, sometimes vomiting | Virus isolation or electron microscopy of biopsy | Intravenous fluids if dehydrated; antibiotics to prevent secondary bacterial infections |
| Toxins | Strychnine,ethylene glycol,lead, zinc | Those left unattended or unsupervised | Loss of appetite, depression, vomiting, dehydration, abdominal pain | History and physical exam; tests (eg., fecal flotation) to rule out other causes; testing of blood, feces or vomit for presence of toxin; x-rays | Depends on toxin |
| Idiopathic Hemorrhagic Gastroenteritis | | Small breed dogs | Sudden onset of bloody vomiting and diarrhea, depression, abdominal pain, black and tarry stools, shock | History; physical exam; complete blood count; tests (eg., fecal flotation) to rule out other causes | Intravenous fluids, antibiotics to prevent secondary bacterial infection, withhold food and water as needed |
| Small intestinal bacterial overgrowth (SIBO); also called antibiotic resistant diarrhea | | German shepherds, dogs with other intestinal diseases | Intermittent watery diarrhea, poor growth or weight loss, increased gas, sometimes vomiting | History; physical exam; intestinal biopsy; tests (eg., fecal flotation) to rule out other causes; ultrasound; blood tests (eg., serum folate and cobalamin, bile acids) | Antibiotics (at least 4-6 weeks); modify diet |
| Tumors | Lymphoma, adenocarcinoma | Middle-age or older | Chronic diarrhea, weight loss, poor appetite; may see vomiting and dark, tarry stools | History; physical exam; intestinal biopsy | Chemotherapy or surgery depending upon the type of tumor |
| Idiopathic inflammatory bowel disease | Granulomatous enteritis, eosinophilic gastroenterocolitis, or lymphocytic/ plasmacytic enteritis (LPE) | Middle-age; LPE in German Shepherds and Basenjis | Chronic vomiting and diarrhea possibly with blood and/or mucus; sometimes straining, mild weight loss, and/or black and tarry stools | History; physical exam; intestinal biopsy; tests (eg., fecal flotation) to rule out other causes | Modify diet, wormers and antibiotics to treat or prevent hidden infections; probiotics; anti-inflammatory drugs; immuno-suppressing drugs if no response to other treatment |
| Histoplasma enteritis or colitis | | Those living in the central US along the Mississippi, Ohio, and Missouri Rivers | Loss of appetite, mild fever, depression, severe weight loss, vomiting, blood in stool, straining; may also have respiratory signs | Endoscopy and biopsy | Itraconazole, ketoconazole or amphotericin B |
| Obstruction | Foreign body,intussusception, pyloric stenosis, splenic torsion | | Diarrhea, vomiting, loss of appetite; as progresses see depression and/or possible abdominal pain | History; physical exam; x-rays; barium series; ultrasound; exploratory surgery | Surgery |
| Pancreatitis | | Dogs eating a high-fat meal; Schnauzers and Yorkshire terriers; middle-aged dogs | Vomiting, dehydration, painful abdomen | History; physical exam;chemistry panel; other blood tests (e.g., PLI or pancreatic lipase immunoreactivity) | Restrict oral intake as needed; administer fluids; provide pain control and other supportive care; medications to control vomiting; maintain on low fat diet |
| Liver or Biliary Disease | Hepatitis, biliary obstruction | | Vomiting; yellow discoloration of gums and whites of the eyes | History; physical exam; chemistry panel; other blood tests; x-rays and/or ultrasound; biopsy | Medications and fluids to control effects of vomiting and liver disease; possible surgery depending on cause |
| Kidney Disease | Pyelonephritis, glomerulonephritis, urinary obstruction | Older dogs | Vomiting, increased thirst and urination; decreased or no urination if obstructed | History; physical exam; chemistry panel; urinalysis; x-rays and/or ultrasound | Diet changes; medications and fluids to control effects of vomiting and kidney disease; remove any obstruction |
| Peritonitis | Perforated intestine | | Vomiting, painful abdomen; sometimes fever | History; physical exam; chemistry panel; complete blood count; x-rays and/or ultrasound | Antibiotics, fluids; medications to control vomiting; possible surgery depending upon cause |
| Pyometra (infection of the uterus) | | Unspayed dogs who have recently had an estrus (heat) | Vomiting; increased thirst and urination | History; physical exam; complete blood count; x-rays and/or ultrasound | Surgical removal of uterus; medical treatment |
| Diabetes mellitus | | Older and female dogs; Schnauzers and Poodles | Vomiting; increased thirst and urination; sometimes depression | History; physical exam; chemistry panel; urinalysis | Insulin therapy; dietary management; supportive care |
| Vestibular disease or brain disease | | Older dogs | Incoordination; vomiting | History; physical exam; possibly MRI | Medications to control vomiting; depends on specific condition |
| Medications | Digoxin, erythromycin, chemotherapy | | Vomiting | History; physical exam; drug levels | Medications to control vomiting; change drug therapy |
| Septicemia | | | Vomiting, fever | History; physical exam; blood culture | Antibiotics; supportive care |
| Hypo-adrenocorticism (Addison's disease) | | Young to middle-age female dogs | Vomiting | History; physical exam; chemistry panel; complete blood count | Medications to control effects of hypo-adrenocorticism |
| Gastritis | Helicobacterinfection; high blood urea nitrogen (BUN); stomach worm | | Vomiting | History; physical exam; endoscopy | Medications to control vomiting and protect stomach; treat underlying cause; fluids, if necessary |
| Ulcers | | | Vomiting; blood in vomit; black, tarry stools | History; physical exam; endoscopy or barium series | Medications to control vomiting and protect lining of stomach and intestines; treat underlying cause; fluids, if necessary |
| Gastroesophageal reflux | | More common in brachycephalic breeds (eg, bulldogs and pugs) | Drooling, licking of lips, vomiting or regurgitation, bad breath | History; physical exam; endoscopy or barium series | Feed small, low-fat meals; medications to help protect esophagus, reduce stomach acid and increase movement of food out of stomach |
| Bilious vomiting syndrome | | May be more common in dogs with giardiasis or inflammatory bowel disease | Vomiting of bile on an empty stomach (usually late at night or early morning) | History; physical exam; endoscopy or barium series | Feed a late night meal; medications to help protect the stomach and increase movement of food out of stomach |
| Motion sickness | | | Drooling, vomiting while riding in a vehicle | History; physical exam | Medications to control vomiting |