Not just Holistic, but how to use E: All of the Above!

I made this blog because I did tons of research on success stories and research worldwide and used it on my dog with nasal cancer named Lucy. So, now my hobby is molecular biology. The treatment uses combination of health store supplements, some prescription meds, diet changes, and specific Ayurvedic and Chinese medicinal herbs. I just wanted her to have a better quality of life. I thought this combination of E: All the Above (except no radiation or chemo and surgery for this cancer was not an option) would help that for sure, but it actually put her bleeding nasal cancer in remission!
My approach to cancer is about treating the whole animals biologic system. But I do hate the word 'Holistic'. Sounds like hoo hoo. This is science based, research based data and results of using active herbal compounds that happen to be readily available and common. Some call it Nutriceuticals. Others may call it Orthomolecular cancer therapy. Or Cancer Immunotherapy.
-Slow cancer cell reproduction
-Make cancer cells become easier targets for the immune system
-Kill the cancer cells
-Rid the cancer cells
-Remove the toxins it produces
- Stimulate and Modulate the immune system
-Control secondary symptoms like bleeding, infection, inflammation, mucous, appetite, or pain for a better feeling animal
-Working with your vet for exams and prescriptions that are sometimes needed when conditions are acute.
Just by using a multi-modal treatment approach that is as diverse in attack as possible. Both conventional and natural.
The body conditions that allowed it to develop in the first place must be corrected. If caught early enough, like with Lucy, this ongoing maintenance correctional treatment is all that was required at this point to achieve, so far, more than 10 TIMES the life expectancy given (more than 60 months) after diagnosis WITH remission. I did not use radiation or chemotherapy or surgery.
I hope this cancer research can help your dog as well.

My Lucy

My Lucy
In Loving Memory my Lucy December 2016
CURRENT STATUS - It was for more than 5 YEARS after Lucy was diagnosed by biopsy in March 2011 with nasal cancer that she lived. And she was in remission for 4 of 5 years using no radiation or chemo! Now multiply that by 7 to be 35 years extended!! She was 12.5 years old - equivalent to almost 90 human years old. She ended her watch December 1, 2016. I miss her so much.

February 8, 2012

NSAIDS for Cancer Therapy

Piroxicam, an NSAID, is a non-selective Cox-1 and Cox-2 inhibitor and has anti-cancer effects in dogs, which is well supported by the veterinary literature. Since those papers, veterinarians have prescribed other NSAIDS such as Deramaxx or Meloxicam, in lieu of Piroxicam, because these newer selective Cox-2 inhibitors are associated with lower rates of side-effects, such as GI ulceration and upset. It is assumed (but not known) that the anti-tumor effects are due to the Cox-2 inhibition, so it is also assumed that cox-2 selective NSAIDs should work as well as piroxicam.
However, this remains to be supported in the veterinary literature. (Not enough studies), but Piroxicam (and possibly other NSAIDS) remains a reasonable palliative option with careful monitoring.

Famotidine (Pepcid AC)

Available in 10 and 20 mg tablets OTC

Stomach ulceration in humans is a prominent medical condition and there has long been pressure to develop effective and convenient ways to control it. Until relatively recently, we relied on simply neutralizing stomach acid by pouring alkaline solutions (i.e., Alka Seltzer, Tums, Rolaids, etc.) into the stomach. In fact, ulceration is a complicated process and there are many ways to address it.
Control of stomach acidity is an important factor in the treatment of stomach ulcers. Acid secretion is controlled by a hormone called gastrin (secreted in the presence of food and leading to secretion of stomach acid), acetylcholine (a neurotransmitter), and histamine (that same substance responsible for the unpleasant allergic effects of hay fever).
Famotidine is a special antihistamine, as are its cousins cimetidine (Tagamet HB) and ranitidine (Zantac). This class of antihistamine is not useful in combating familiar allergic symptoms (itching, sneezing, stuffy nose etc.) In allergy, histamine causes unpleasant effects by binding so-called H1 receptors. Famotidine, ranitidine, and cimetidine instead bind to histamine receptors in the stomach called H2 receptors.
Cimetidine was the first such H2 blocker available and each generation has brought about improvements in terms of fewer drug interactions and stronger effect. Famotidine is the longest lasting of the H2 blockers (usually one dose lasts 24 hours). Famotidine is 32 times stronger in its ability to inhibit stomach acid than is cimetidine and is 9 times stronger than ranitidine. A newer H2 blocker called nizatidine is now available that offers the additional advantages of especially rapid onset of action and some effect on normalizing stomach contractions as well.

Famotidine is currently available in an over-the-counter formulation making it highly convenient for pet owners to obtain (though obviously one should not consider using medications licensed for human consumption without specific instructions from one's veterinarian). Famotidine is especially useful for pets with chronic vomiting.

How This Medication Is Used

Famotidine is useful in any situation where stomach irritation is an issue and ulceration is a concern. It is often used in the treatment of Helicobacter infection, inflammatory bowel disease, canine parvovirus, ingestion of a toxin or medication that could be ulcerating (NSAIDs, like Metacam Meloxicam Peroxicam Duramaxx aspirin and others, for example), any disease involving protracted vomiting, or chronically in combination with medications which may have stomach irritating properties.
In diseases involving frequent vomiting or regurgitation, the esophagus (tube connecting the mouth and stomach) can be ulcerated by continuing exposure to vomit/stomach acid. Antacids are also helpful in this type of situation to reduce damage to the esophagus. Megaesophagus would be a condition where a long-acting antacid such as famotidine could be helpful in mitigating injury to the esophagus.

Side Effects

The H2 blockers as a group have a limited potential for side effects, hence their recent release to over-the-counter status.
There have been some reports of exacerbating heart rhythm problems in patients who already have heart rhythm problems, so it may be prudent to choose another means of stomach acid control in heart patients.
Interactions With Other Drugs
There are some drugs that are absorbed better in the presence of stomach acid (example: itraconazole). The dose of such drugs may require adjustment in the presence of famotidine.
Concerns and Cautions
The dose of famotidine may require reduction in patients with liver or kidney disease as these diseases tend to prolong drug activities.
It appears that famotidine is safe for use in pregnancy but should probably be avoided during lactation.