Not just Holistic, but how to use E: All of the Above!

I made this blog because I did tons of research on success stories and research worldwide and used it on my dog with nasal cancer named Lucy. So, now my hobby is molecular biology. The treatment uses combination of health store supplements, some prescription meds, diet changes, and specific Ayurvedic and Chinese medicinal herbs. I just wanted her to have a better quality of life. I thought this combination of E: All the Above (except no radiation or chemo and surgery for this cancer was not an option) would help that for sure, but it actually put her bleeding nasal cancer in remission!
My approach to cancer is about treating the whole animals biologic system. But I do hate the word 'Holistic'. Sounds like hoo hoo. This is science based, research based data and results of using active herbal compounds that happen to be readily available and common. Some call it Nutriceuticals. Others may call it Orthomolecular cancer therapy. Or Cancer Immunotherapy.
-Slow cancer cell reproduction
-Make cancer cells become easier targets for the immune system
-Kill the cancer cells
-Rid the cancer cells
-Remove the toxins it produces
- Stimulate and Modulate the immune system
-Control secondary symptoms like bleeding, infection, inflammation, mucous, appetite, or pain for a better feeling animal
-Working with your vet for exams and prescriptions that are sometimes needed when conditions are acute.
Just by using a multi-modal treatment approach that is as diverse in attack as possible. Both conventional and natural.
The body conditions that allowed it to develop in the first place must be corrected. If caught early enough, like with Lucy, this ongoing maintenance correctional treatment is all that was required at this point to achieve, so far, more than 10 TIMES the life expectancy given (more than 60 months) after diagnosis WITH remission. I did not use radiation or chemotherapy or surgery.
I hope this cancer research can help your dog as well.

My Lucy

My Lucy
In Loving Memory my Lucy December 2016
CURRENT STATUS - It was for more than 5 YEARS after Lucy was diagnosed by biopsy in March 2011 with nasal cancer that she lived. And she was in remission for 4 of 5 years using no radiation or chemo! Now multiply that by 7 to be 35 years extended!! She was 12.5 years old - equivalent to almost 90 human years old. She ended her watch December 1, 2016. I miss her so much.

April 26, 2012



Pubmed Cit:
Palliation with chemotherapy: The addition of chemotherapy to radiation therapy has not resulted in significantly improved survival times.  It is, however, often effective in relieving clinical signs.  Median survivals of 5 months are reported for patients with nasal adenocarcinoma treated with cisplatin chemotherapy (J Am Vet Med Assoc 200[3]:355-357 Feb 1’92).  A more recent study presented at the Veterinary Cancer Society meeting in 2003 showed survival ranges of 5-32 months when doxorubicin, carboplatin and piroxicam  were used in combination.
Other studies also found that just using Piroxicam or P with doxo alternated worked almost as well!

Piroxicam -COX generic anti-inflammitory with antiangiogenesis properties. Most COX do not do antiangio well.

Piroxicam Links:

A new treatment for canine malignancies is available.  Piroxicam, a non-steroidal, anti-inflammatory drug, is now in the treatment arsenal of veterinarians.  Sold under the trade name Feldene, piroxicam is a popular prescription familiar to many as a human arthritis medication.
The interesting point for STCA members is that prioxicam is showing an effectiveness in treating maliganancies to which Scotties seem to have a greater risk than some other breeds.  Quoting the 1986 Scottish Terrier Club of America Handbook article Diagnosis and Treatment of Some Common Malignancies in the Scottish Terrier, "it would appear that genetics plays a significant role in the development of cancer.  Epidemiologic studies have shown that the Scottish Terrier has a higher than expected incidence of lymphosarcoma, bladder carcinoma, oral melanoma, cancer of the skin (squamous cell carcinoma and mast cell sarcoma), and to a lesser extent, nasal carcinoma and gastric carcinoma."  (1)
These are the same malignancies which recently have been treated with good results in piroxicam studies at Purdue University School of Veterinary Medicine.  This new therapy has meant a much improved quality of life in a 10-year-old female Scottie of mine.  She was diagnosed with transitional cell carcinoma of the bladder in September 1992.  Surgery, radiation and chemotherapy all give quite disappointing results with this type of bladder cancer, indicates the above 1986 STCA cancer review.  We are pleased with the results of piroxicam therapy.
Lucky, our old C.D. obedience dog, started having accidents in winter, 1991, at 9 years old.  Urinalyses on several occasions revealed no infection, though there were microscopic traces of blood.  Our local veterinarian, Dr. Scott Burt, Big Spring, TX, suggested diethylstilbesterol (DES), an estrogen therapy that can help female incontinence caused by weakening of the muscles that control bladder action.  But he cautioned that the accidents and straining to urinate might be evidence of early bladder malignancy.  Routine blood work not long after had shown elevation of the serum alkaline phosphatase enzyme which sometimes indicates presence of malignancy.  Cancer ws a distinct possibility.  And, affirmed the 1986 STCa cancer article, "It can be extremely difficult to differentiate clinically between chronic bladder infection, stones and cancer."
DES seemed to improve the situation temporarily.  Lucky headed for college as a bed-dog for our son Scott.  Later, off at school, there were more accidents.  This time blood was in the urine, obvious to the eye.  Home Lucky came in June, 1992, for a recheck.  Dr. Burt x-rayed for possible bladder stones or a malignant growth.  There was no evidence of either.
By September, 1992, Lucky's puddles were centered with large spots of blood.  Dr. Burt ran positive and negative cystograms, radiologic dye studies of the bladder.  This time the news was defenite, and bad.  There was a growth at the neck of the bladder.  It was so obstructive to the pathway into the bladder that Dr. Burt could not use the usual French 8 catheter to insert dye into the bladder.  He had to resort to the smallest French 3«.  Cell studies at Texas Veterinary Medical Diagnostic Laboratory confirmed Dr. Burt's tentative diagnosis of transitional cell carcinoma of the bladder.
The options?  Surgery, radiation, chemotherapy, or nothing.  The nearest surgical specialist was 300 miles away.  Even for a specalist, the tumor would be hard to reach and tricky to excise completely.  Dr. Burt predicted that the tumor's location probably would require breaking Lucky's pelvis, and that the delicacy of operating at the narrow neck of the bladder would make it nearly impossible to remove all the malignancy.  Prognosis, even with surgery, would not be good.  There isn't much hope for transitional cell carcinomas.
Breaking her pelvis would guarantee Lucky would complete her life as a cripple, and the surgery also might leave her totally incontinent, instead of only partially.  Our family decided we couldn't put a 10-year-old dog through such trauma.  We opted to let our dog live out whatever time might be left as normally as possible at home.
The first two weeks after the cystogram were not good.  There were more accidents than ever, with large quantities of blood.  Lucky was listless.  She lost a pound, a noticeable loss for a 15-pound Scottie that never misses a meal.
Sadly, we figured Lucky had only a very few weeks left and took her back down for a college weekend and a final farewell to Scott.  That weekend was full of last photos.  I investigated cremation.  We expected the end soon.
Back in Big Spring, the nice surprise was that there was still something we could try.  Dr. Burt had checked with oncologist at Texas A & M University College of Veterinary Medicine.  Clinicians there were having some success with piroxicam cancer therapy pioneered by Purdue's vet school.  Oncologist Dr. Claudia Barton suggested we use piroxicam with Lucky.
Dosage prescribed for a dog the size of a Scottie required me to reformulate the drug.  I became something of a pharmacist.  The 10 mg capsules are too strong for a Scottie.  Recommended dosage is 0.3 mg/kg every 48 hours.  For Lucky's 15 pounds, that means three doses per capsule.  One capsule lasts six days.  To prevent breakdown of the drug because of its possible instability in liquid, I mix one capsule at a time with pharmaceutical syrup.  The mixture is split between three syringes (to be given orally) and refrigerated until used.
In the Purdue clinical trial reported in a 1992 issue of Cancer Chemotherapy and Pharmacology, piroxicam was given to 62 dogs.  A fairly complete range of cancers was studied.  Tumor types were 10 transitional cell carcinomas, 10 melanomas, 9 osteosarcomas, and smaller numbers of fibrosarcomas, hemangiopericytomas, squamous cell carcinomas, mammary adenocarcinomas, perianal gland adenocarcinomas, anal sac adenocarcinomas, lymphomas, mast-cell tumors, nasal carcinoma, mammary adenoma, transmissible veneral tumor, synovial cell sarcoma and lipoma.  Though no complete remissions occurred, eight partial remissions were documented in 3 of the 10 dogs with transitional cell carcinoma of the bladder, in 3 of the 5 animals with squamous cell carcinoma, in 1 of 3 dogs with mammary adenocarcinoma, and in the one dog with transmissible veneral tumor.
Complete tumor remission in two dogs bearing malignant hemangiopericytoma and metastatic carcinoma was observed in an earlier Purdue study using piroxicam.  A previous human clinical trial of piroxicam with 31 cancer patients having pulmonary metastasis also had shown one complete response and give "minor regressions" of malignancy.
Additionally, Purdue later reported use of piroxicam in 24 dogs, all with transitional cell carcinoma of the bladder.  These tumor responses at 60 days were 0 complete remissions, 4 partial remissions, 11 stable diseases, and 8 progressive diseases.  Preliminary analysis showed a median survival of 150 days (range 30 to 510 days) with 8 dogs alive at the time that the report was written.
Veterinarians at Texas A & M have used piroxicam therapy for about a year and have been pleased with the results.  "the good thing about piroxicam therapy is that the dogs feel pretty good," said oncologist Dr. Barton.  She notes, "We still recommend radiation followed by surgery, if the tumor is in a site where it can be reached."
Dr. Barton does not claim that piroxicam is a miracle drug.  She describes results at Texas A & M which are similar to those at Purdue:  about   dogs responding with decreased tumor size,   with stable disease, and   with progressive disease.  "But," she emphasizes, "that's better than other results we've had."
The results at Texas A & M have been obtained with half the dose originally used in the 1992 Purdue research, and patients have exhibited fewer gastrointestinal problems.  Piroxicam can cause serious GI bleeding like any NSAID taken continually, according to Dr. Barton. (JUST GIVE PEPCID PLUS USE METRONOMIC ALTERNATING PROTOCOLS)
"We have tested the tumor size with sonography.  It does appear tumors get a little smaller with piroxicam," indicates Dr. Barton.  "There may be some chemotherapeutic benefit, but we're not particularly impressed with tumor shrinkage."  She explains that improvement may be due to reduced edema and reduced inflammation rather that true tumor reduction.
"We feel like piroxicam gives comparable results to those we get with cisplatin chemotherapy or radiation," say Barton.  The advantage, Dr. Barton repeats, is:  "the dogs feel good, and they get to stay at home. "  Disadvantages Barton ascribes to the common cisplatin chemotherapy include severe nausea, vomiting and kidney toxicity.  And with radiation treatment, dogs must be hospitalized four to five weeks for the 12 to 15 treatments, according to Barton.
Purdue also compared its piroxicam results to similar cases treated with cisplatin, the currently used chemotherapy in canine transitional cell carcinoma.  The tumor response and survival date of the two drugs were similar, but the toxicity of piroxicam treatment was much less that that of cisplatin treatment, according to Purdue.
From my own experience with a Scottie, piroxicam has been a bit of a miracle.  We expected a steady deterioration and speedy demise of our pet.  Instead, five months after beginning piroxicam therapy our dog acts like a 10-year-old puppy.  Next month she will be 11.  The first three months of treatment Lucky almost stopped having accidents, and the ones she had weren't bloody.  The fourth month of treatment she did start having frequent accidents again, and they remain bloody.  (2) However, Lucky feels good!
The only side effect of piroxicam therapy has been an occasional day with minor nausea and spitting up.  There's an occasional time like the morning she tipped over her bowl of kibble and tried to bury the food disgustedly under her kennel rug.  Two hours later her belly must have been back to normal.  She knocked the same bowl off a crate top to get at every crunchy bite and then scavenged a jar of throw-away bacon grease from the trash.
Lucky retains her great interest in food.  She is active, can still work up a game of soccer.  She delights in life and appears in no pain.  What more could we wish for a cancer patient?
Without treatment of any kind, transitional cell carcinoma of the bladder can claim a dog's life in a very short time, as little as one to three months or less, according to Dr. Barton.  With piroxicam therapy, Dr. Barton projects a more usual survival time of 9 months.
At this point, it's been about a year from what must have been Lucky's first signs of bladder cancer, and five months since diagnosis of cancer and beginning treatment with piroxicam.  We still have milestones ahead with Lucky.  We had our one more Christmas, now maybe one more birthday next month, perhaps even one more walk in the neighborhood 4th of July parade.  The end has not changed, but piroxicam has been a gift of time, more importantly, a gift of quality time.
For future reference, please write the following addendum in your 1986 STCA Handbook following the article, "Diagnosis and Treatment of Some Common Malignancies in the Scottish Terrier".
Piroxicam (Feldene) therapy is being used with good results in treatment of some canine malignancies.  Recent suggested regimen:  0.3 mg/kg piroxicam every 48 hours.
Reference:  Dr. Claudia Barton, Professor of Oncology, Texas A & M University College of Veterinary Medicine, College Station, TX.
"Piroxicam Therapy in 24 Dogs with Transitional Cell Carcinoma of the Bladder."  D. W. Knapp, R. C. Richardson, et al.  Proceedings of the 9th Annual ACVIM Forum, New Orleans, LA, May, 1991. p. 896.
"Phase I Trial of Piroxicam in 62 Dogs Bearing Naturally Occurring Tumors."  D. W. Knapp, R. C. Richardson, et al.  Cancer Chemotheraphy and Pharmacology. 29: 214-218, 1992.
(1)  Of genetic interest is that one litter mate of our Lucky is known to have died with transitional cell carcinoma at about 9 years old.  Lucky's breeder is deceased, so we do not know if these are the only two closely related dogs in that line to have had transitional cell carcinoma.  Lucky is a spayed female, and was never bred, so implications in her own offspring are impossible to determine.
(2)  During the first several months of her piroxicam therapy, Lucky received Vitamin C supplementation daily, unrelated to her cancer treatment and unprescribed by a veterinarian.  About 1,000 mg ascorbic acid crystals were added to her evening meal.  For no special reason, I stopped Vitamin C supplementation, then about two months later added it to Lucky's diet again.  I noticed that, upon receiving Vitamin C again, Lucky almost immediately had fewer accidents and that there was much less blood in them.  Thinking back, the time when Lucky stopped receiving Vitamin C was about the time she started having bloody and frequent accidents.  I have no scientific evidence that Vitamin C is a hepful adjunct of piroxicam therapy, but I can't help but wonder.  I have sent this information to Dr. Barton for her comment.

Carprofen as Alternative?
Meloxicam / Metacam also. I read that Metacam is easier on the stomach.

Recently, subtotal prostatectomy with a neodymium: yttrium-aluminum-garnet laser has been suggested as palliative treatment for prostatic neoplasia with and without metastasis.44 Subtotal prostatectomy was followed by a one-time injection of interleukin-2 (4.5 million IU in 1 ml normal saline) into the remaining prostate and ongoing once-daily administration of 0.1 mg/kg meloxicam (an NSAID that primarily inhibits cyclooxygenase [COX]-2).44 The survival time of eight dogs that underwent this treatment protocol ranged from 5 to 239 days (median: 103 days), and postoperative urinary incontinence did not develop in any dog. Medical treatment with COX inhibitors alone has also been advocated in dogs with prostatic carcinoma.53 Inhibition of COX-2, which is expressed by 88% of prostatic carcinomas,53 is thought to result in a decrease in tumor cell proliferation, an increase in apoptosis of tumor cells, and inhibition of tumor angiogenesis. Dogs treated with COX inhibitors (e.g., piroxicam, carprofen) survived significantly longer than dogs that did not receive NSAIDs, with a median survival time of 6.9 months and 0.7 month, respectively.53 

Can't Live with out it (piroxicam)
“My dog byron who is 6 years old has nasal cancer. Our vet gave him a 3 month life expectancy. They put him on this medication and ever since then he has been doing great. He is now on month 5 and is larger then life, he hasn't changed a bit. He is just as happy as he was if he was still a puppy. “


Dogs were given piroxicam (Pfizer, New York, NY) at a dosage of 0.3 mg/kg every 24 h p.o., alone for 4 weeks, followed by piroxicam combined with cisplatin (60 mg/m2 i.v. every 21 days). Cisplatin was provided by Bristol Laboratories, Bristol-Myers Squibb Co., Princeton, N.Y. Diuresis was induced by administering 0.9% saline i.v. at a rate of 18 ml/kg/h for 4 h before and 2 h after cisplatin administration. Then, saline was given at a rate of 5 ml/kg/h for 15 h. Cisplatin was administered i.v. over a 20-min period. Butorphanol (Torbugestic; 0.4 mg/kg i.v.; Fort Dodge Laboratories, Fort Dodge, IA) was given 30 min before cisplatin to decrease vomiting.


Antitumor Activity and Toxicity of Piroxicam/Cisplatin.

Subject characteristics are summarized in Table 1. Fourteen privately owned pet dogs were enrolled in this study. Dogs had no other major co-morbid diseases. Two dogs received three doses of cisplatin, five dogs received two doses of cisplatin, and seven dogs received one dose of cisplatin. Two dogs were not evaluated for piroxicam/cisplatin response because of early withdrawal from the protocol caused by toxicity. The toxicity associated with piroxicam/cisplatin is summarized in Table 2. Tumor response, apoptotic index, proliferative index, and bFGF and VEGF concentrations are summarized in Table 3.


The median survival for 14 dogs was 329 days (range, 97–1000 days), with one dog still alive at 973 days. Seven dogs survived more than 1 year.  (CHEMO ALONE DOES NOT EXTEND LIFE USUALLY, MORE PALLIATIVE. THE COMBO DID EXTEND, SO PEROXICAM MUST BE THE DEAL WITH INF AND ANTIANGIO)

Induction of Apoptosis.


What about ALTERNATING  Doxycycline usage with Peroxicam?
The metronomic protocols are always using a Peroxicam with either low dosage Chemo and or the old antibiotic Doxycycline.

One of the cheapest, safest, and most easily obtained through a vet? Doxycycline.  Now, doxycycline is not a dream antibiotic.  It actually has fairly limited use as an antibiotic.  Some use it for dental infections, but it is most commonly used to treat certain blood parasites.
Some exciting news about doxy?  It has anticancer effects!
Doxycyline helps suppress angiogenesis (new blood vessel formation that feeds tumors and robs the body). In this way it slows tumor growth. It blocks enzymes called matrix metalloproteinases (MMP’s) that digest the tissue around tumors, allowing new blood vessels to be formed. Check it out here.
Not having access to as much blood supply, the cancer cells are less able to metastasize through the circulation.  This lessens the spread of some cancers.
In the lab, this drug can induce apoptosis (normal, healthy, programmed death) of cancer cells.  This is a direct action on the cancer cells, and may have some usefulness in cancers like lymphosarcoma. 

My opinion and usage of above research in Lucy's Cancer:
I simply opted to use what the above meds were doing and replace with naturally occurring substances in their whole form. Anti-inflammatory COX-2 , Apoptosis (normal programmed cell death), and Anti-Angiogenic (slowing down of blood vessel formation to tumor) herbs and supplements used.
 View the list of stuff I use for Lucy and why.