Not just Holistic, but how to use E: All of the Above!

I made this blog because I did tons of research on success stories and research worldwide and used it on my dog with nasal cancer named Lucy. So, now my hobby is molecular biology. The treatment uses combination of health store supplements, some prescription meds, diet changes, and specific Ayurvedic and Chinese medicinal herbs. I just wanted her to have a better quality of life. I thought this combination of E: All the Above (except no radiation or chemo and surgery for this cancer was not an option) would help that for sure, but it actually put her bleeding nasal cancer in remission!
My approach to cancer is about treating the whole animals biologic system. But I do hate the word 'Holistic'. Sounds like hoo hoo. This is science based, research based data and results of using active herbal compounds that happen to be readily available and common. Some call it Nutriceuticals. Others may call it Orthomolecular cancer therapy. Or Cancer Immunotherapy.
-Slow cancer cell reproduction
-Make cancer cells become easier targets for the immune system
-Kill the cancer cells
-Rid the cancer cells
-Remove the toxins it produces
- Stimulate and Modulate the immune system
-Control secondary symptoms like bleeding, infection, inflammation, mucous, appetite, or pain for a better feeling animal
-Working with your vet for exams and prescriptions that are sometimes needed when conditions are acute.
Just by using a multi-modal treatment approach that is as diverse in attack as possible. Both conventional and natural.
The body conditions that allowed it to develop in the first place must be corrected. If caught early enough, like with Lucy, this ongoing maintenance correctional treatment is all that was required at this point to achieve, so far, more than 10 TIMES the life expectancy given (more than 60 months) after diagnosis WITH remission. I did not use radiation or chemotherapy or surgery.
I hope this cancer research can help your dog as well.

My Lucy

My Lucy
In Loving Memory my Lucy December 2016
CURRENT STATUS - It was for more than 5 YEARS after Lucy was diagnosed by biopsy in March 2011 with nasal cancer that she lived. And she was in remission for 4 of 5 years using no radiation or chemo! Now multiply that by 7 to be 35 years extended!! She was 12.5 years old - equivalent to almost 90 human years old. She ended her watch December 1, 2016. I miss her so much.

February 11, 2013

Bloodroot Neoplasene Berberine Oregon Grape Root Cancer Uses

One of the main health benefits of the Bloodroot herb determined from recent studies is that Bloodroot herbal extract has certain anti-cancer agent properties that are useful in the treatment of skin cancer. It has also been established that Bloodroot contains a chemical substance called berberine which helps fight tumors in the brain and several other types of cancers.  Bloodroot extracts are used in minimal doses to treat bronchial infections and sore throats. Bloodroot tinctures have been used over several centuries in treating bleeding lungs, pneumonia, the common cold, whooping cough, croup, laryngitis, emphysema and sinus congestions.  The root of Bloodroot has the ability to work well as an anesthetic, carthartic, emetic, expectorant, diuretic, sedative and stimulant. Bloodroot also helps in effective peripheral blood circulation. It has been used in treating liver conditions like jaundice. 

Bloodroot contains berberine, a substance that may fight cancer and brain tumors. Berberine is an alkaloid found in Bloodroot and it exhibits tumoricidal and anti-carcinogenic properties. One study, published in April 2002 edition of Biochemical Pharmocology, found that these sanguinarine alkaloids caused cell death in multi-drug-resistant human cervical cells. . Sanguinarine, a plant-based compound with very similar chemical classification as berberine.  Often used as a home remedy for skin cancers in humans and animals, Bloodroot provides the main ingredient for homemade black salves, which can cause dangerous side effects when used incorrectly. 

Neoplasene is a relatively new drug now available for veterinary use (Rx from vet only)  that is derived from the perennial herb bloodroot (Sanguinaria canadensis), so named because of the reddish sap of the root.  It has historically been used as a dye, an emetic (induces vomiting) and a wart and tumor treatment, esp. by Native Americans.  In external cancers it has been used as a caustic escharotic paste called Black Salve, which "burns" any flesh it comes into contact with, whether it is healthy or not.  This is indiscriminate necrosis.  Neoplasene is really not Black Salve it is not whole bloodroot.   It is, only in part, an isolate of the active ingredients of bloodroot called benzylisoquinoline alkaloids, with the primary one being sanguinarine. 
Neoplasene® process stimulates the immune system by killing cancer cells.  It causes cancer cells to die by a process known as apoptosis.  This is a self termination process.  The immune system of the patient is then stimulated to handle them as it would any other dying cells, by way of inflammation.  It does all this while sparing healthy, normal cells.  This makes it extremely unique and valuable.  So, unlike most conventional “chemo” treatments it is not toxic at recommended doses (except to cancer cells).  Furthermore, according to the most current information, unlike most conventional chemo treatments, Neoplasene works on any type of cancer cell.

Contraindications:  Large oral internal doses of Bloodroot are poisonous. Too much can be fatal. In toxic oral doses, it causes burning in the stomach, intense thirst, vomiting, faintness, and vertigo. Self-medications should not be attempted with Bloodroot as unwanted visual  distortions can occur even in small doses. Large doses of Bloodroot can irritate your mucous membranes. It makes you really nauseous if not very careful . Neoplasene is fine for external use.

Berberine has drawn extensive attention towards its antineoplastic effects.[63][64] It seems to suppress the growth of a wide variety of tumor cells, including breast cancer,[65] leukemia, melanoma,[66] epidermoid carcinoma, hepatoma, pancreatic cancer,[67] oral carcinoma, tongue carcinoma,[68] glioblastoma, prostate carcinoma and gastric carcinoma.[69][70] Animal studies have shown that berberine can suppress chemical-induced carcinogenesis, clastogenesis,[71] tumor promotion, tumor invasion,[72][73][74][75][76] prostate cancer,[77][78][79][80] neuroblastoma,[81][82] and leukemia.[48][83]

Berberine is a plant alkaloid with a long history of medicinal use in both Ayurvedic and Chinese medicine. It is present in Hydrastis canadensis (goldenseal), Coptis chinensis (Coptis or goldenthread), Berberis aquifolium (Oregon grape), Berberis vulgaris (barberry), and Berberis aristata (tree turmeric). The berberine benzylisoquinoline alkaloids can be found in the roots, rhizomes, and stem bark of the plants.

From modern biomedical studies, anticancer effects have been demonstrated in berberine. The underlying molecular mechanisms involve cell-cycle arrest, apoptosis induction and anti-inflammation. Berberine is an essential anticancer compound. Berberine also demonstrates effects of antiangiogenesis, anti-invasion and anti-metastasis in some cancer cell lines, however, more investigations are required to unravel the underlying mechanisms involved.

It is also a radiosensitizer of tumor cells, but not of normal cells. How berberine mediates these effects is not fully understood, but its ability to inhibit angiogenesis and to modulate Mcl-1, Bcl-xL, cyclooxygenase (COX)-2, MDR, tumor necrosis factor (TNF)- and IL-6, iNOS, IL-12, intercellular adhesion molecule-1 and ELAM-1 expression, MCP-1 and CINC-1, cyclin D1,[84] activator protein (AP-1), HIF-1, PPAR-, and topoisomerase II has been shown. By using yeast mutants, berberine was found to bind and inhibit stress-induced mitogen-activated protein kinase kinase activation. Because apoptotic, carcinogenic, and inflammatory effects and various gene products (such as TNF-α, IL-6, COX-2, adhesion molecules, cyclin D1, and MDR) modulated by berberine are regulated by the transcription factor nuclear factor- B (NF- B), it is postulated this pathway plays a major role in the action of berberine.[85] Berberine suppressed NF-κB activation induced by various inflammatory agents and carcinogens. This alkaloid also suppressed constitutive NF-κB activation found in certain tumor cells. It seems to protect against side effects of radiation therapy in lung cancer.[86]

Berberine extracts and decoctions have also demonstrated significant antimicrobial activity against a variety of organisms including bacteria, viruses, fungi, protozoans, helminths, and chlamydia. Currently, the predominant clinical uses of berberine include bacterial diarrhea, intestinal parasite infections, and ocular trachoma infections.

A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs.
Sun Y, Xun K, Wang Y, Chen X.
School of Pharmacy, Chengdu Medical College, Chengdu, China.

Natural products represent a rich reservoir of potential small chemical molecules exhibiting antiproliferation and anticancer properties. An example is berberine, a protoberberine alkaloid widely distributed in medical plants used in traditional Chinese prescriptions. Recent advances have shown that berberine exerts anticancer activities both in vitro and in vivo through different mechanisms. Berberine shows inhibitory effects on the proliferation and reproduction of certain tumorigenic microorganisms and viruses, such as Heliobacter pylori and hepatitis B virus. Transcriptional regulation of some oncogene and carcinogenesis-related gene expression and interaction with both DNA and RNA are also well documented. Besides, berberine is a broad spectrum enzyme inhibitor, which affects N-acetyltransferase, cyclooxygenase-2, and topoisomerase activities and gene/protein expression. These actions, together with the regulation of reactive oxygen species production, mitochondrial transmembrane potential, and nuclear factor-kappaB activation might underlie its antiproliferative and proapoptotic effects. More importantly, the suppression of tumor growth and metastasis, the beneficial application in combined medication, and the improvement of multidrug resistance both in vivo and in vitro clearly show its potential as an alternative medicine for tumor chemotherapy.
PMID: 19704371  [PubMed - indexed for MEDLINE]

^ Sun Y, Xun K, Wang Y, Chen X (20 August 2009). "A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs". Anticancer Drugs 20 (9): 757–69. doi:10.1097/CAD.0b013e328330d95b. PMID 19704371.
^ Tang J, Feng Y, Tsao S et al. (August 2009). "Berberine and Coptidis Rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations". Journal of Ethnopharmacology 126 (1): 5–17. doi:10.1016/j.jep.2009.08.009. PMID 19686830.
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^ Sindhu G, Manoharan S (April 2010). "Anti-Clastogenic Effect of Berberine against DMBA-Induced Clastogenesis". Basic Clin Pharmacol Toxicol. 107 (4): 818–24. doi:10.1111/j.1742-7843.2010.00579.x. PMID 20406204.
^ Pandey MK, Sung B, Kunnumakkara AB, Sethi G, Chaturvedi MM, Aggarwal BB (July 2008). "Berberine modifies cysteine 179 of IκBα kinase, suppresses nuclear factor-κB-regulated antiapoptotic gene products, and potentiates apoptosis". Cancer Research 68 (13): 5370–9. doi:10.1158/0008-5472.CAN-08-0511. PMID 18593939.
^ Kim JB, Ko E, Han W, Shin I, Park SY, Noh DY (November 2008). "Berberine diminishes the side population and ABCG2 transporter expression in MCF-7 breast cancer cells". Planta Medica 74 (14): 1693–700. doi:10.1055/s-0028-1088313. PMID 18951337.
^ Kim S, Choi JH, Kim JB et al. (2008). "Berberine suppresses TNF-α-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cells". Molecules 13 (12): 2975–85. doi:10.3390/molecules13122975. PMID 19052522.

^ Liu J, He C, Zhou K, Wang J, Kang JX (January 2009). "Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cells". Biochemical and Biophysical Research Communications 378 (2): 174–8. doi:10.1016/j.bbrc.2008.10.169. PMID 19000652.
^ Thirupurasundari CJ, Padmini R, Devaraj SN (February 2009). "Effect of berberine on the antioxidant status, ultrastructural modifications and protein bound carbohydrates in azoxymethane-induced colon cancer in rats". Chemico-biological Interactions 177 (3): 190–5. doi:10.1016/j.cbi.2008.09.027. PMID 18951886.
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^ Li GH, Wang DL, Hu YD et al. (September 2009). "Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy". Medical Oncology (Northwood, London, England) 27 (3): 919–25. doi:10.1007/s12032-009-9307-8. PMID 19757213.

Swanson Premium Full Spectrum Oregon-Grape Root -    LUCY GETS 1 Capsule at PM meal
Oregon-Grape Root CONTAINS BERBERINE – VERY SIMILAR TO BLOODROOT(THE COMPOUNDS IN BLACK SALVE and NEOPLASENE). IT HAS ANTI-ANGIOGENIC, IMMUNE MODULATION, APOPTOSIS, AND COX-2 properties, TNF, TIP cells and more. Also antibiotic, anti-inflammatory, antiparasitic. But the Oregon Grape Root's Berberine won't make them sick to their stomach like bloodroot or Neoplasene. Stimulates white blood production from the bone marrow, anti-cancer properties, supports liver function.


"I would be willing to try neoplasene on a tumor on the outside of the body or a tumor that was not internal but could fall off after it died . But I would not try it on nasal cancer or a cancer deep inside the body.
 Neoplasene causes inflammation in the cancer cells and that causes apoptosis to occur ( cellular suicide) so you get alot of swelling and in the nasal passages there is not a lot of room so he would get very stuffed up. He was also on the anti-angiogenesis protocol from his oncologist which cuts off the blood supply to a tumor and his oncologist was a bit hesitant to doing both as neither he nor the holistic vet had done both at the same time but after they talked they thought maybe just maybe hitting a tumor at the blood supply and then from the surface with a drug that might cause apoptosis might just work. It may have been working but we will never know for sure or maybe it was working too fast or maybe it was not working and this was just the natural progression of the cancer but eventually Dash did develop swelling on his muzzle and for several months it did not grow but suddenly it got huge, swelled his eye shut and then it ruptured. All the other dogs I got to know on here or via another site that had nasal cancer treated with neoplasene also died and one thing we all seemed to have in common was the difficult act of even getting it down the nose as many of us used it via nose drops and it was a battle. Some gave it orally but I know it can then cause GI issues such as bleeds so Dash's doctor did nose drops instead."